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Heart Disease Community
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Over time, atheromata usually progress in size and thickness and induce the surrounding muscular central region of the artery to stretch out, termed remodeling, typically just enough to compensate for their size such that the caliber of the artery remains unchanged until typically over 40-50% of the artery wall cross sectional area consists of atheromatous tissue.
If the muscular wall enlargement eventually fails to keep up with the enlargement of the atheroma volume, then the lumen of the artery begins to narrow, commonly as a result of repeated ruptures of the covering tissues separating the atheroma from the blood stream (can cause thrombosis...blod clot). This becomes a more common event after decades of living, increasingly more common after people are over 40 years old.