CNS tumours

[jitendra83]

45 yr.old male recently diagnosed asSOL brain in Right frontoparietal region after investigated for sudden onset of altered sensorium, left sided hemiplegia and diabetic ketoacidosis.MRI angiography imression was oligoastrocytoma or glioblastoma multiforme.According to neurosurgeons advice we immediately taken decision for excision of that tumour and operated..Histopath of excised tumour found to have anaplastic astrocytoma grade 3..what should be next line of management? how is overall prognosis?should we go for radiotherapy alone or chemo and radiation? what about steretactic radiotherapy,ita side effects and any preventive measure?

[dr_simran]

Hello Dear,
Usually combination of chemotherapy and surgery is opted. Stereotactic radiosurgery uses sophisticated computerized imaging to precisely target a narrow X-ray beam. Using this method, it is possible to effectively destroy small tumors or close down abnormal blood vessels.
.The side effects may be - Swelling: As with all radiation treatments, the cells of the irradiated tumors lose their ability to regulate fluids, and edema or swelling may occur. This does not happen in all treatments. If swelling does occur, and it causes symptoms that are unpleasant, then a mild course of steroid medication may be given to reduce the fluid within the tumor cavity.
Necrosis: The tumor tissue that remains after the radiation treatment will typically shrink. On rare occasions this necrotic or dead tissue can cause further problems and may require removal. This occurs in a very small percentage of cases.
Refer http://www.irsa.org/radiosurgery.html
Best