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Has your sister seen a neurologist? The one-sided weaknesses and "some loss of trunk control" could indicate a neuro problem....
I am going through testing right now to try and figure out what caused a TIA that I had back on Aug 8th. I have had the Echo with Bubble and there where bubbles in the third chamber but they could not confirm a PFO based on the test results. I am getting a referral to Cardiology and I had a CAT scan and a contrasted MRI back on Aug 8th and they confirmed no Stroke, no tumor, no anurism and no brain bleeding. Tomorrow I meet with the "Stroke Resident" of the Neurology Dept. at MGH so everyone is telling me that I am in good hands and that I just need to go through the tests and see what happens.
So what can cause bubbles in the third chamber that is not an ADS or a PFO?