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'Blisters are most common on the hands and feet, as these extremities are susceptible while walking, running, or performing repetitive motions. Blisters form more easily on moist skin than on dry or soaked skin, and are more common in warm conditions.
Short periods of intense rubbing can cause a blister, but any rubbing of the skin at all can cause a blister if it is continued for long enough.'
http://en.wikipedia.org/wiki/Blister
To avoid blisters on the hands, gloves should be worn when using tools such as a shovel or pickaxe, doing manual work such as gardening, and handling detergents, cleaning products, solvents and other chemicals.
A lubricant, typically talcum powder, can be used to reduce friction between skin and apparel. People put talcum powder inside gloves or shoes for this purpose.
Sunscreen and sun protection should also be used during the hottest part of the day to avoid blisters from sunburn, and moisturizing, after-sun or calamine lotions can help to ease discomfort.'
You should consult your doctor for a clinical examination and to find out the cause of the lesion in your case.
Let us know if you need any further information.
Regards.