Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from
absorbing too much salt, which can cause fluid retention.
Spironolactone is a potassium-sparing diuretic that also prevents your body from absorbing too
much salt and keeps your potassium levels from getting too low.
The combination of hydrochlorothiazide and spironolactone is used to treat fluid retention
(edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called
nephrotic syndrome. This medication also treats high blood pressure (hypertension).
Hydrochlorothiazide and spironolactone may also be used for other purposes not listed in this
medication guide.