Misoprostol reduces stomach acid and replaces protective substances in the stomach that are
inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin.
Misoprostol is used to prevent the formation of ulcers in the stomach during treatment with
aspirin or an NSAID such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis
KT, Oruvail), naproxen (Naprosyn, Aleve, Anaprox, Naprelan), oxaprozin (Daypro), indomethacin
(Indocin), diclofenac (Voltaren, Cataflam), etodolac (Lodine), piroxicam (Feldene), meloxicam
(Mobic), tolmetin (Tolectin), nabumetone (Relafen), and fenoprofen (Nalfon). NSAIDs and aspirin are
used to treat pain, fever, arthritis, and inflammatory conditions.
Misoprostol may also be used for purposes other than those listed in this medication guide.