Promethazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It
works by changing the actions of chemicals in your brain. Promethazine also acts as an antihistamine. It
blocks the effects of the naturally occurring chemical histamine in your body.
Promethazine is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or
watery eyes, hives, and itchy skin rashes.
Promethazine also prevents motion sickness, and treats nausea and vomiting or pain after
surgery. It is also used as a sedative or sleep aid.
Promethazine is not for use in treating symptoms of asthma, pneumonia, or other lower
respiratory tract infections.
Promethazine may also be used for other purposes not listed in this medication guide.