Leucovorin is a form of folic acid. Folic acid helps your body produce and maintain new
cells, and also helps prevent changes to DNA that may lead to cancer. Folic acid is present in
many foods such as dried beans, peas, oranges, spinach, and others.
Leucovorin is used to reduce the side effects of large doses or accidental overdose of
medications that can reduce the effects of folic acid in the body. This includes methotrexate
(Rheumatrex), pyrimethamine (Daraprim), trimethoprim (Trimpex, Proloprim), and others.
Leucovorin may also be used to treat anemia (lack of red blood cells) caused by
chemotherapy.
Leucovorin may also be used for purposes other than those listed in this medication guide.