Enoch Choi, MD  
Male, 43
Palo Alto - CA

Specialties: Family Medicine

Interests: sinusitis, migraine, low back pain, cellulitis, abscess, skin infection, neck pain, allergies, ear infections

Palo Alto Medical Foundation Urgent Care
650-853-4761
795 El Camino Real
Palo Alto - CA
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Fluoroquinolones increase risk of tendon rupture in elderly, transplant recipient, steroid users

Jul 08, 2008 11:38AM - 27 comments
Tags:

tendon

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rupture

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side effect

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adverse

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ADE



This new box warning via FDA is something i've been aware of for some time in patients using ciprofloxaxin, levaquin (levofloxacin), Moxifloxacin (Avelox), ofloxacin (floxin), gatifloxacin (tequin), and i'm glad it'll be highlighted on labeling, showing it's increasing incidence:

risk of tendinitis and tendon rupture is further increased in those over age 60, in kidney, heart, and lung transplant recipients, and with use of concomitant steroid therapy. Physicians should advise patients, at the first sign of tendon pain, swelling, or inflammation, to stop taking the fluoroquinolone, to avoid exercise and use of the affected area, and to promptly contact their doctor about changing to a non-fluoroquinolone antimicrobial drug. Selection of a fluoroquinolone for the treatment or prevention of an infection should be limited to those conditions that are proven or strongly suspected to be caused by bacteria.

Read the complete MedWatch 2008 Safety Summary, including a link to the 'Information for Healthcare Professionals' page, at:

http://www.fda.gov/medwatch/safety/2008/safety08.htm#Fluoroquinolone

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Critical Incident Stress Debriefing in Silicon Valley

Apr 14, 2008 08:12PM - 1 comments
Tags:

Grief

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Counseling

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Critical Incident Stress Debri

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debriefing



It's wonderful to know that in Silicon Valley, there's a group called Kara
http://www.kara-grief.org/help_advice.htm
that is available for Critical Incident Stress Debriefing by their volunteers.  Very responsive, and can mobilize their volunteers very rapidly.  I'll be adding comments in the coming days to this journal as I reflect on their help in a difficult situation at my children's school

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1st annual Sutter Health EpiCare User Group meeting

Apr 10, 2008 04:20PM - 1 comments
Tags:

EMR

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EHR

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electronic medical record

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electronic health record

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EpiCare

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Epic



schlepped over to Concord, CA for a full day meeting with 300 physicians across Sutter.  Great talks from Phil Strong (who organized the day and who i worked on his startup in the past), Elliot Wong (my urgent care subject matter expert team lead), Albert Chan (PAMF physician champion), Steven Lane (Sutter Ambulatory EHR lead).

the most important thing from the day was to tell the 2 developers Sal Abiezzi (fellow PAMF MD) and I had lunch with, that the most important thing wasn't new and snazzy features.  The most important thing is to make our current use of EpiCare more efficient, decrease the number of clicks it takes me to get through the day so i can spend more time with patients.

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Antidepressants may not be much better than placebo

Feb 26, 2008 03:07PM - 44 comments
Tags:

antidepressant

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treatment

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depressed

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prozac

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effexor

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serzone

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paxil

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placebo

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Depression



A fascinating research study was published today by Irving Kirsch of the University of Hull, questioning whether or not 4 popular antidepressants are any better than placebo, and found that they weren't any better.  Here's the study:

http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050045&ct=1

Both published and unpublished data on fluoxetine (Prozac), venlafaxine (Effexor), nefazodone (Serzone), and paroxetine (Paxil) were combined in a technique called meta-analysis, which brings together the data from many different research studies to see if they agree.

The researchers concluded that the antidepressants were not any better than placebo for mildly depressed patients.  They found that although there was a benefit from antidepressants, it was not significantly better than what a placebo (pill without any medicine in it) did.  The placebo treatments had a great deal of benefit, almost 80% improvement in depression symptoms.  The antidepressants didn't do any better than placebo.

They further concluded that the benefit that these antidepressants had on severely depressed patients was from these patient's lack of benefit from placebo treatment.  That is to say, severely depressed patients didn't get better from a placebo (pill without any medicine in it).  Since severely depressed patients got better at about the same rate as the mildly depressed patients, by comparing this benefit to the lower benefit from placebo, overall they showed a benefit.  Another way to think of it is that really depressed patients get better from antidepressants at about the same rate as mildly depressed patients get better, but since severely depressed patients don't get better from placebo, by comparing treatment versus placebo, the difference is greater.

It's important that patients on these medicines don't stop taking their medicines because serious side effects can occur, such as worsening of the depressive symptoms that they initially took them for, including thoughts of suicide for some patients.

This is just one study that will be further examined.  The great thing is that it's been published in the Public Library of Science online journal.  This is a place where the data and paper are publicly available, without any advertising or corporate support.

Reasons to think twice about the results of this study, is that the technique of meta-analysis is only as good as how well the 47 different data sets they've combined match.  These data sets have to be combined in a valid way, controlling for different factors in each study.  Some researchers disagree with this kind of process, saying that it's very difficult to control for confounding factors in the separate data sets, calling into question the validity of the results.  I'm expecting the drug companies to be fighting these studies powerfully, and be curious to see how they try to disprove the results.