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Hepatitis C Acronyms and some Definitions:

May 17, 2015 - 0 comments

HCV - Hep C : Hepatitis C virus
Boceprevir: Victrelis
Teleprevir: Incevik
Inf: Interferon

GS-7977 Experimental drug by Gilead Sciences Inc. Phase 3 trials underway in conjunction with Rbv

Riba/Rbv: Ribavirin
Bx: Biopsy : Invasive liver sample removed and analized to determine liver condition
Fibroscan: Non invasive Ultrasound Technique for determining liver condition
Fibrosure/Fibrotest: Combination of blood test scores used for determining liver condition
Dx: Diagnosis
GT: Genotype
IR: Insulin Resistant
IL28B: A gene polymorphism which helps in Tx prediction -  CC , CT , TT
Sx: Side effects
Tx : Treatment

SOT: Start of Treatment
EOT: End of Treatment
RVR: Rapid viral response - Undetected virus at 4 wks. Tx
cEVR: Complete Early Viral Response: PCR Und at Week 12 (P/R Tx)
EVR: Early Virological Response:  >2 Log Drop at Wk. 12
eRVR - Extended Rapid Viral Response - Und virus @ Wk.4 - Wk. 12
Und : Undetected virus
SVR: Sustained Viral Response: Und after 6 months EOT
P/R Tx: Pegelated Interferon / Ribaviron Treatment (old term - SOC: standard of care)
VL: Viral Load - amount of virons per IU (International Unit)
IU: International Unit (1 IU = 2.5 VL Copies apx )
HVL: High Viral Load (≥800,000 IU)
LVL: Low viral load (<800,000 IU)

PCR: Polymerase Chain Reaction
RT-PCR quantitative: using Reverse Transcription-Polymerase Chain Reaction- to count how many virus are in blood

RT-PCR qualitative: a "positive" or "negative" using Reverse
Transcription-Polymerase Chain Reaction to see if there are at least 50 IU/mlviruses detected in bloodRNA: RiboNucleic Acid
Rx: Prescription
TMA: Transcription Mediated Amplification
All oral Tx: Interferon-free treatment (Phase 2 Clinical Trials)

More Acronyms:

AFP: Alpha-FetoProtein
ALP: Alkaline Phosphatase (Alk Phos)
ALT/SGPT: Alanine Aminotransferase - liver function blood test
AST/SGOT: Aspartate Aminotransferase - liver function blood test
CBC: Complete Blood Count
DAA: Direct Acting Anti-viral
ELISA: Enzyme-Linked ImmunoSorbent Assay
EPO: Erythropoietin Epoetin alfa (Epogen/Procrit), Darbepoetin alfa (Aranesp)
ESA:: Erythropoiesis Stimulating Agent
ESLD: End-Stage Liver Disease
GGT:: Gamma Glutamyl Transpeptidase
HCC: HepatoCellular Carcinoma (Liver Cancer)
HDL: High Density Lipoproteins (Good Cholesterol)
HGB: Hemoglobin
IFN: Interferon (Alpha 2a/2b)
IU: International Unit 1 IU (2.5 VL Copies apx)
LDL: Low Density Lipoproteins (Bad Cholesterol)
LFT: Liver Function Test
LLN: Lower Limit of Normal
NAFLD: Non Alcoholic Fatty Liver Disease (Steatosis)
NASH: Non Alcoholic SteatoHepatitis
Neup: Neupogen
PEG: PolyEthylene Glycol
PegIFN: Pegylated Interferon Alpha (2a/2b)
PI : Protease Inhibitor
RBC: Red Blood Cell Count
RIBA: Recombinant ImmunoBlot Assay
TMA: Transcription Mediated Amplification
TSH: Thyroid stimulating hormone or Thyrotropin
ULN: Upper Limit of Normal
VLDL: Very Low Density Lipoproteins
WBC: White Blood Cell Count

Vietnam Veterans Help

Dec 30, 2014 - 0 comments








I found this site looking for information.  It talks about a Veteran winning a HCV disability case that recognizes transmission via jet guns, there is a lot more information/help on this site.  I hope this helps someone.

Bloodwork normal!

Mar 04, 2012 - 11 comments

While it has not been a long time 3 weeks since last shot all of my blood work from Feb 27th 2012 has come back normal  UND!  I am so excited, the albumin is a tad over normal for the first time in my life.  I know from the last time that tx can do things to results so am trying not to get upset about it.  The last time it took close to a year for my blood work to normalize.
My platelets are normal (168 up from 75) for the first time since 2004, yippee
I am so happy I am floating.
Again, I want to thank everyone who helped me through this tx, my doc said it would be hard for me and he was right

Thank you

Worst week 13

Dec 03, 2011 - 15 comments





side effects



I am not doing well.  I finished 12 weeks of Incivek last Saturday, did ok for a couple of days, then I started having anxiety, did not sleep Mon,Tues,Wed,  Thursday I slept for a couple of hours.
Last night was pretty bad but I tried melatonin and it helped.  Will try to write more when I get some sleep

Update, Today is Dec 12th close to midnight, what a time it has been since I first wrote the above Dec 2012.  I have really suffered sinc Nov 29th 2012. when I finished the Incivek.   I already described the panic I was feeling  in a post  half in CAPS, and I did not realize. I am really embarrassed by that post.  I was having a panic attack  due to medication interactions when I wrote the post..  I had a choice to remove it but thought it might help someone else.

I finished Incivek for the first couple of days I was ok, not great but ok.   Then, a few days after, all of a sudden I could not read...could not write, could not express a coherent thought.  I was very afraid I was having a stroke.  My husband took my blood pressure and pulse.  He said I was ok.  I still wonder to this day if I did have a stroke.
New information regarding Incivek and drug interactions have come out since I started tx Sept 1st 2011. I have written up a time line to hopefully cut and past tomorrow.  I am exhausted, my husband has been sick since last week and since it is just the two of us it is difficult so we are leaning on each other. .  I let my docs office keep telling me that it was the medicine.  Yes, of course it is the medicine however I did a triple trial in 2008 and when I stopped the trial drug at 16 weeks continuing on with peg/riba to 43 of 48 weeks I did not notice any difference so I knew something wasn't right.
Today I was told that when any new drug is approved by the FDA there are always side effects which do not become obvious until many many months or years later.  It made sense to me.  Why did I rush into treatment?  I thought they had researched this for years, drug approved May 23, I started Sept 1st  As my friend NYGIRL(7) posted, they have been studying this for years why don't they have something for the rash and the horrible itching? (this was not what she said verbatim but I caught the drift) :) .

Update  11/17/13  There was some new information presented at the EASLD conference of 2013. I will get it bring it back here.

I was looking for help with tx for another member here and came across this. It is a poster from the EASL 2013.  It was s a small study