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Glutamate Antagonists

Aug 12, 2008 - 4 comments
Tags:

glycine

,

Glutamate Antagonists

,

Tardive Dykinesia

,

Recovery

,

advocacy

,

Rhodiola



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If anyone wants to know my story I am on glycine, a glutamate antagonist. It is in FDA study in Phase II and part of a new class of medications that unlike the current anti-psychotics don't cause tardive dyskanesia or diabetes and are much more effective. I have had a full recovery. I am working with my psychiatrist to advocate within the system to get these new medications out. If someone is unfamiliar with these medications feel free to e-mail me. The difficult yI have now is extreme forms of tardive dyskanesia. I take muscle relexants for it as I could not tolerate the anti-Parkinson's medications (and couldn't tolerate Clozaril which also was unhelpful to me) and they are not very effective. I am on a natural remedy also in FDA study called rhodiola which has been of great help. But all of these medications are activating and with the severe effects of the tardive conditions such as full body spasms I am homebound so I telecommute to earn enough money to keep the Medicaid Buy In for Working People with Disabilities. However, I also advocate for people with disabilities in general areas such as benefits applications and appeals. I assist people within a certain area near me in person but I can provide information to anyone. Right now my primary concern is learning how to cope with the severe physical disability and use the increased mental functioning and I"m doing well. I just have to build up some weight as the tardive akathesia and other variants of the motor disorders causing me to remain in motion as well as the activating effects of the medications have caused weight loss. I've moved beyond the aspect of "recovery" of mentally recovering but there is the physical recovery but right now what's more important to me is to advocate and help others so if anyone reads this and wants to more information send me a message.

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by lindakl, Sep 12, 2008
This is my horror story.  My son was functioning fine in mid-high.  He was raped by four boys, could never tell what happened to him because he was threatened with great physical harm.  Kids were members of a satanic cult which drew a mark on my son Chris.  I knew more that a mark had occured.  With six weeks he went from a;s and b;s to flunking every class.  He was terrified to go to class.  There were meetings, taking him out of class ect and to make a long story short.  Chris was hospitalized with depression and treated with a toxic level of desiprimine in combination with 80 milligrams of haldol.  His vital signs were taken in four months only ten times.  He developed a sub-clinical case of neuroleptic malignant syndrome.  He can never take antipsychotics again.  His IQ went from 137 to a 60 during this four months.  He never showed any signs of schizophrenia no hallucinations, nor experienced any type of thought disorder until he was given such high doses at toxic levels of both medications.  After this hospitalization he would have terrible episodes just as you have described as tardive psychosis.  Yet notheng seemed to help.  It "resembled' schizophrenia but I as a therapists and never saw any of the classic signs.  I believed he was having some type of temporal lobe seizure as well as his psychiatrists.  He was hospitalized, treated with antipsychotics and came out after each hospitalization more disabled.  He has tardive everything including I believe tardive psychosis.  If any of these new treatments work at all it would truly be a miracle and I would be forever grateful.

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by ILADVOCATE, Sep 12, 2008
Since I wrote this I have been on Zofran which is used experimentally for tardive dyskinesia and the psychosis associated with Parkinsons' Disease. I advocated to get on it and its been extremely helpful and its controlling what they are now studying as tardive psychosis. As for antipsychotics, Clozaril cannot cause any tardive condition and a person who needs an antipsychotic could take that. As well there are newer antipsychotics in study such as the glutamate antagonists. I am on glycine, a glutamate antagonist that is part of a phase II FDA study. My psychopharmcologist is allowing for me to take it outside of study and it is available through the company but must taken under the care of a psychopharmocolgist. Tardive psychosis even in studies did not lower i.q. There is a hypothetical condition tardive dementia but it has been even less studied. If you look up any information make sure its a factual source. These two conditions although studied by the APA have been misused by the anti-psychiatry movement to claim people with schizophrenia don't need medication which is a blatant falsehood. Tardive psychosis at least in me is beginning to look like a reality but the psychiatric researcher still has to study me and write it up. But since so many adverse events happenned to your son, including neuraleptic malignant syndrome which does have permanent after effects have him see a neurologist to rule other conditions out. But do inquire about Zofran which many neurologists are starting to use.

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by Vajra, Sep 15, 2008
Fascinating recovery story and and thanks for the post about glycine and Zofran.
can you tell us a little bit more about your advocacy services?  Always good to know as a resource.  Where are you located?


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by boopx, Oct 17, 2012
thank you so much for writing your story, you are a great help to many people who suffer from these terrible medications. i also have suffered with tardive psychosis and nev er seemed to have these problems before. can you please tell me where and how you were able to get a prescription for glycine?? i am desperate to get off these medications but am terrified of getting ill again. how can you be prescribed these drugs? please, please get back to me, i dont know where else to turn and cannot find anyone else who is on these.

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