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Successful with my own eggs after 2 1/2 yrs of treatment.  Did these help??

Jan 18, 2012 - 8 comments

After having three failed IUIs, two failed IVFs, and one IVF resulting in a miscarriage I really felt I had nothing to lose in my endeavours to get pregnant and complete my family with a much wanted third child.  

Here is a list of what I added to my IVF (ICSI) cycle last October.  I am now going on 17weeks pregnant, and pray eveything turns out fine finally.  I am not recommending any of these things, as it is important for every individual to research on their own and decided what they are willing to add to their cycle, but, I want to list them so others can choose to look into them if they wish.  

Of all the medicines, supplements and procedures I added, MELATONIN, MYO-INOSITOL, VITAMIN E,  VITAMIN D3, SAIZEN, INTRALIPID, and the HYSTEROSCOPY were the ones which were added for the first time to this last successful cycle and one of them could be the answer to my ongoing BFP!

There is a lot being written up about melatonin in conjunction with Vitamin E.  Also a lot of research and positive findings regarding Myo-inositol.  The other supplements all seem to have properties thought to improve egg/embryo quality.  DHEA is quite a big one being used by many women, and some fertility clinics prescribe it to older women.  The pycnogenol and Trans-Resveratrol are supplements that I notice quite a few doctors actually recommend.  As with most remedies, you will find positive research and then you'll find negative research, so before you start taking any of these, please look into them yourself, as I'd hate to recommend anything you think has an adverse effect.  I also started weekly acupuncture with a fertility expert about three months prior to my cycle.  I continued it through the cycle and also 13 weeks into my pregnancy.  

The other thing I did was ask my RE to perform a HYSTEROSCOPY prior to my last successful IVF cycle.  This is a quick procedure where a camera is inserted so your uterus can be seen.  I knew there was nothing wrong with my uterus, but the reason for me having it done was so that my RE could scrap away a piece of the endometrium so that a scar formed.  There have been statistics showing that the procedure can increase pregnancy rates, as the scarred endometrium makes implantation more successful.  

I also asked my RE to prescribe SAIZEN last cycle when I started the stimulation drugs for IVF.  (I used the micro-dose flare protocol, with 225iu of puregon, plus 2 x daily shots of buserelin).  Saizen is a human growth hormone, and is often used in older women or women with egg quality issues.  Also, this last cycle, I was prescribed with prednisone.  I started on this a day after egg collection, and kept taking it up to 7 weeks gestation.  

All this time, I've kept off caffeine and I think it's best to keep off alcohol.  I don't drink alcohol, and think maybe it's not great for fertility, although there's nothing documented about it.  

The other BIG thing I tried this successful cycle was INTRALIPID.   I was worried about the possibility of my having an auto-immune problem, as my ANA was high when it was tested in 2008.  Intralipid was given to me the day I started stimulation drugs.  It was also administered  the week I received my BFP, and then at 5 - 6 week intervals after that.  Now I'm almost 17 weeks, I won't be having anymore intralipid as my RE thinks the risk of a reaction may outweigh the benefits at this stage.  

Fish oil - Omega 3, with EPA and DHA
Myo-Inositol (must be myo-inositol, not just inositol)
Melatonin (3mg)
Vitamin E (600mg)
Vitamin D3 (1,000 IU)
Wheatgrass in powder form
Royal Jelly, liquid form best, but capsules still OK
Bee propolis
l'arginine
CQ10 (800mg)
DHEA (75mg - 3 x 25mg daily)  
DIM
Pycnogenol
Trans-Resveratrol (some RE's actually recommend this in conjunction with Pycnogenol)
Green tea (one cup per day)
Maca
Low dose aspirin

I used vitex for my third cycle from memory, but cut it out after reading some not so good reports on it.  

Now, I'm not necessarily saying any of these things contributed to my now being pregnant, but after 2 1/2 years of heartache,  in my heart, I do feel that something did help me this time.  Maybe the intralipid, maybe the hysteroscopy, or even the saizen or myo-inositol?  Who knows?  

Please don't start taking these things without looking into them yourself.  All I want to do is to list them, and let people know that after using them, I did get pregnant.  

The one last important thing is to have a specialist who realistically believes in you.  My first RE unreasonably gave up on me after my first IVF failure.  He thought I should be happy with two children, and after my miscarriage last May, went on to say the only way I'd achieve another pregnancy was if I used a young egg donor.  I wasn't willing to do this, as I had two young children and wasn't ready to give up on my own eggs.  I changed to another RE at the same clinic who believed another pregnancy was indeed possible and that donated eggs should be Plan 'D'.  His confidence in my ability to have another genetic child gave me extra confidence.  And this is very, very important in this game.  

Good Luck everyone!!!!  Patience, perserverance and a fair amount of money (if you're like me and had to pay out of pocket) are often the key to getting pregnant with your own eggs!!!  Especially once you're over 35!  

XOX


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by stacey10, Jan 19, 2012
this all sounds great :) in may I'm to start dhea for 3 months to see how I go, at the moment I'm having acupuncture once a week and am on the following:

pre-conception prenatals
royal jelly
vital greens
bee pollen
macca
evening primrose oil
coconut oil

at different times I've also taken coq10 but as this is in the pre-conception  tablets wasnt sure if I would be taking too much, also the same with the fish oil caps, will def also look into the melatonin, vit E as well thanks for the post :)

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by Marietta2000, Jan 19, 2012
You're so welcome stacey10.

There is so much said about older women's fertility problems all lying with decreased egg quality, but there are some experts who don't believe egg quality can decline so rapidly.  Hormonal fluctuations as we age have a lot to do with our inability to conceive.

It's great you're doing acupuncture and DHEA.  Plus those others you're on are really beneficial.  I took all of those I've listed and wondered if maybe I was overloading, but obviously they didn't do any harm.  Will you be doing IVF?  I see you already have children, wonderful!!  How many do you have?

All the best in making your dream of another baby come true!!  If you ever have any questions, just ask! SSBD!!  :0)

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by stacey10, Jan 19, 2012
I've got 10, the youngest being 8mths and I had the overian test reserve done and I freaked as it showed that I was basically infertile, so I havent got the leasure of waiting 1-2yrs and then deciding that I want another, I've been doing acupuncture on and off for the last 6 yrs, everytime I've wanted to concieve, so from around 39 I think I started it :) looking forward to starting the dhea in may, have to stop breastfeeding before I can go on it, thats the delay, as bub will be 1 by then and it didnt feel right to wean him early just so I could go on it, I usually try and feed until they're 2 so it was a hard decision, but I figure 1 is an ok age, I'm off to get everything else this weekend, my specialist was extremely happy with what I was taking/doing and all he could reccomend was the dhea, ivf isnt an option for us, I'm still tracking my ovulation and had the worst O pain that I've ever had in my whole life last friday and the darkest opk line that I can remember as well, I probably should wait until I've been on the dhea for the 3 mths but I always think ":but what if this is a good egg"lol,  had a blighted ovum in nov and he couldnt believe that I had ovulated and managed to get pregnat while breastfeeding a 6mth old considering my age as well :) did you get any of the good side effects from the dhea? I hope I do :) I think thats half the reason why I looking forward to taking it so much I think lol...

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by Marietta2000, Jan 20, 2012
Wow, ten children!!!!  You're a mega mom!!!!  Are they all yours genetically?  If so, I'd say you have a great chance of conceiving another, as your fertility is obviously excellent!  I wouldn't worry much about the ovarian test as you may still have good quality eggs left there, even though there may be less of them!  If you're TTC naturally, just go for it, as you've got nothing to lose!  I had a blighted ovum last April/May.  I was devastated as I'd never miscarried before.  About the DHEA, I can't say I had any adverse effects from it, and didn't notice any positive effects.  I do know some women break out and get oily skin, and then some have said they get more energy when on it, but I was totally fine and I was taking it for months.  Hopefully it will do you some good!!  I always get sharp pain around ovulation which often lasts for days.  Have you had a pelvic ultrasound done to rule out any cysts?  I weaned my children when they were close to 1yr.  I wanted to feed them longer, but my son kept on biting the older he  got, and with my daughter, I wanted to conceive again & since I was doing medicated IUI, I had no option but to stop.  I'm so looking forward to being able to breastfeed again though, as I never thought I'd get the chance ever again!  Any questions, let me know.  But I'm sure you'll be pregnant very soon.  You're a super mom!!!!  :0)

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by Moroca, Oct 08, 2012
Hi everyone I would like to know how many units of Saizen did you used my doctor prescribed 0. 25 IU and obviously it didnt worked.
I am going on a new cycle on November 2012 Thankyou for posting all this information
XOXO

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by Marietta2000, Oct 09, 2012
Hi Moroca!  

I've just had a look through my records, and it seems I was on 3mg a night.  Of course that measurement is different to IU and I don't know how it can be converted.  I guess I was on the standard dose - I'd never used it before, but since it was going to be my last attempt before moving to other options, I demanded my RE add it to my plan.  As you've read, I also used intralipid, among many other things.  If you need to know anything else, let me know.  And GOOD LUCK!!!

XOX

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by sfgirl03, Nov 28, 2012
I hear Intralipid can be expensive.  How much did that cost you?  I am out of pocket and curious as to how much that costs.  Also, normally people use intralipids to prevent a miscarriage, why did you use it during your stims.  I haven't heard that it helps with egg development.  Did you find research that it helps with egg quality or development?

Also, may I ask how old you are?  I'm over 40 and wanted to know if you were successful over 40.

Let me know. Congratulations again!!!  Stories like this are inspiration and give us hope to keep trying.  Thank you for sharing your story with us!

Linda

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by Marietta2000, Dec 01, 2012
Hi Linda!

I used intralipid to help with any immune problems I suspected I might have had in trying to have my third child.  I had a high ANA after I had my second baby & I thought that maybe this was stopping me completing my family.  I didn't use it to improve egg or embryo quality.  The intralipid was relatively cheap compared to all the other fertility treatment I had to pay for, it only cost me $250.00 per session.  I had one the day I started stimming, then I had one a couple of days after I got my BFP, then three more monthly treatments, stopping at around 15 or 16 weeks into my pregnancy.  I really think it was the difference between my previous BFNs & miscarrigae & a successful pregnancy.  My little girl, (my third & last child) is now five months old, & I'm so pleased I found out about the intralipid treatment.  I know of many, many women who've had years of disappointment & miscarriages & then tried intralipid & gotten BFPS & babies!

For egg/embryo quality I used saizen, plus many other supplements I have listed above.  I also used prednisone & anti-biotics plus aspirin.  Please let me know if you need any more advice or help.  I really hope you're successful!  I conceived my first baby at age 32yrs, second at age 35 then 39yrs with my last child.  I turned 40 on June 4 & had my last bubba on June 25!

Good Luck my friend!  Perserverance & Patience is the key, & not worrying too much about the $$$$$ if you're not covered by insurance.  I spent around $60k in treatment to have my last child!

:0)

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