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Terri Warren, RN, Adult Nurse Practitioner  
Female
Portland, OR

Specialties: STI/STD

Interests: Herpes Simplex, Herpes, HSV-1, HSV-2
Westover Heights Clinic
503-226-6678
Portland, OR
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Genital Herpes Research Going Strong!

Aug 23, 2012 - 94 comments
Tags:

Genocea

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AiCuris

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Agenus

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Westover Heights Clinic

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decrease viral shedding

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hsv2



After years of nothing new in herpes research, everything is new right now.  Nationally, there are at least three different studies beginning for the treatment of genital herpes.  First, the Genocea phase one (first in humans) trial.  Instead of an oral medication to treat herpes, Genocea out of Boston has taken the approach of stimulating the immune system to respond more robustly to the herpes virus in people who are already infected with the virus.  The routinely available oral medicines interfere with replication of the virus, but this treatment is designed to allow the immune system to respond more effectively to the virus and subsequently reduce the frequency of recurrences and reduce viral shedding.  This phase 1 study is being conducted at several sites in the US.  For more information contact Jessica Rowlands at Feinstein Kean Healthcare, 202-729-4089.

The next research study is sponsored by AiCuris, a German company. This is a phase 2 trial, the phase 1 trial complete two years ago.  The results of the phase 1 trial indicate that this oral medicine has excellent activity against the herpes virus.  The newest study will compare the AiCuris drug against Valtrex, an FDA approved medicine for the treatment of genital herpes.  For more information about research sites conducting this study, please contact AiCuris.  Information Email:    info-at-aicuris-dot-com

Finally, another therapeutic vaccine trial starting in October from a company called Agenus.  This is another attempt at enhancing the immune response to herpes as a way to decrease the frequency of recurrences and viral shedding for people already infected with HSV 2. For site locations as well as additional study information, you can contact Westover Heights Clinic in Portland, Oregon at:   westoverheights.com.

After years of nothing much new in the genital herpes treatment scene, we have three exciting new prospects for treating this challenging STD.

Terri Warren, RN, ANP
Westover Heights Clinic
2330 NW Flanders, Suite 207
Portland, OR  97210
phone    503-226-6678
fax         503-226-4307

Comments
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by gracefromHHP, Aug 23, 2012
great to hear Terri!!!

unfortunately the email addy's got bleeped out. perhaps repost them with at instead of the symbol so folks can contact the people you listed?

I know I'd personally love to be freed up from remembering to take pills twice a day for my herpes after 25 years of doing so! I hope some of the theracines prove to be worthwhile :)



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by gracefromHHP, Aug 23, 2012
http://www.clinicaltrials.gov/ct2/show/NCT01658826?term=genital+herpes&recr=Open&rank=2   this is the link to the clinical trial for the aicuris drug.

http://www.clinicaltrials.gov/ct2/show/NCT01667341?term=genital+herpes&recr=Open&rank=4  this is the link to the clinical trial for the genocea vaccine.



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by Heather3418, Aug 23, 2012
Ms. Warren,

Do you believe these trials for treating HSV-2 may lead to advancements in the treatment for HSV-1?  This is an equally troubling virus, as you know.  Unfortunately, it is a virus that can be "seen" by everyone, but just as contagious as HSV-2.

Thank you.

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by sweets702, Aug 29, 2012
So Im so scared and not to sure how to use this site, I see that you have answered many of peoples questions and I really need help.

I found out I was pregnant April of 11 was tested for everything under the sun and was negative for HSV2 but I have had HSV1 for my whole life. One evening I had itching near my anus, 2 days later I had small blisters that looked just like the ones I get as a coldsore.

I went to my doc he looked at it and said it was not herpes but I begged him to test me. I cam back just 2 points over what would be considered positive. I have been with one person since the birth of my son and he says he has never had anything happen to him like that. But he does have a red area on his penis that get irritated every now and again. no blisters or anything.

Questions:
1) can that area be herpes on him?
2) can you only spread herpes from the site of where you have an outbreak with skin to skin contact?
3) discharge associated with herpes, is it contagious?
4) Ive started taking Valtrex 500mg but I am breaking them in half and it is keeping my symptoms at bay. Is that ok??

I have read and researched so much and can not find these answers, if there is any information you can enlighten me with I would greatly appreciate it.

Thank you again!
M

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by jjpatrick135, Aug 30, 2012
Sounds encouraging.  The first treatment that you mentioned is it an injection?  and is the treatment used during the dormant phase of HSV-1 and HSV-2?  Can any of these treatments have the potential to actually cure the virus?

Also is acyclovir effective during the dormant phase? or is it best suited for when you feel an outbreak coming?

Thanks!

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by rich371, Sep 07, 2012
It is always exciting to hear about this type of stuff. It is more exciting to hear that they are trying to enhance the ability of the body to fight rather than jsut adding a new medication.

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Sep 07, 2012
Yes, the first treatment is an injection.  It is just used, people can have outbreaks during the study or not.  It is given at specific intervals for the study.  

Acyclovir is effective during the dormant phase, if you mean times when you don't have outbreaks.  it can also be taken as soon as symptoms are noticed.

The treatments for HSV 2 are usually effective against HSV 1 as well.  Acyclovir and valacyclovir are very effective

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by slotsubop, Sep 08, 2012
Thank you Terri!  Can one become immune to Acyclovir after taking it for some time, where it wont work anymore?  Some times I'll double the dose when I hava breakout to help speed recovery as per my Dr.  How much is too much per day?

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by gracefromHHP, Sep 08, 2012
slotsubop  - you need to pay to ask questions about your situation to Terri. you can post them for free on the herpes patient to patient forum.

grace

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by slotsubop, Sep 08, 2012
Thank you!


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by Terri Warren, RN, Adult Nurse PractitionerBlank, Sep 09, 2012
I'm OK with answering this question.  We don't see resistance, no.  Good thing, huh?
Terri

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by Lynn9973, Sep 09, 2012
Terri -
Thanks for posting the encouraging news. I'm a 38 year old female who has had a acyclovir resistant strain for 13 years. I have baffled dozens of doctors and specialists because I continue to have OBs even when uses what would be considered mega doses of Acyclovir, Valtrex or Famvir. I've been tested for everything else under the sun, but my only sure diagnoses is GHSV-2 which was positively cultured in my inital OB.

In some of the online H forums that I participate in, there are quite a few other people like me. Ten years ago there were not, but today, I know at least a dozen people who either don't respond to the antivirals, or who continue to have breakthrough OBs even on suppressives. God bless these researchers who are searching for a new and different mechanism of action against this virus, since the existing 3 meds all work on one particular enzyme. I am likely TK-deficient, so none of them can help me. Please continue your great work with making the medical community aware of people like me.

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by Smart7, Sep 09, 2012
Hi Teri,
You must have been having a little bit of a bad day since you listed AIC-316 for Aicuris as going into a phase II trial when they are actually going into a phase III.  I know you have been a great leader in the fight for HSV treatments and I am grateful for your service.  So thank you for all you have done.  To answer someone else’s question, the projects mentioned are treatment options.  It might be possible that the vaccines could bring about a functional cure, which means no more outbreaks and enough of a reduction in shedding to not be able to transmit the virus to another person.  However we don’t know at this time if that will be the case and it may take years of study before we will know.  A sterilization cure would be to rid the body of the virus.  I have been keeping a close eye on current research along with many others in the genital herpes community.  Great strides are taking place with treatment options such as those Terri mentioned.  Microbicides like Starpharma’s Vivagel, other vaccine options such as Dr. Bill Halford’s vaccine candidate and Dr. Ian Frazer’s candidate from Coridon which are prophylactic vaccines.  There is also viral eradication research going on such as my favorite which uses ZFN technology to disrupt the viral DNA within the neurons and will hopefully be developed through Restrizymes.  This approach is also being considered for HIV, HPV, and Malaria infection.  Those are just to name a few.  I happen to be an admin of a secret research group.  I am also affiliated with a new organization called projectaccept.org.  This is a brand new organization for all people who suffer from incurable STD’s to come together to bring more awareness, fight the stigma, and eventually fund CURE research.  I think most people don’t know that there is really not a whole lot of funding for research that would actually bring a cure.  Hopefully that will change since it is now clear that Genital Herpes increases ones chances of acquiring HIV.  Studies completed at the University of Washington have proven the case.  It is my hope that the STD community comes together to help fund such research projects for bringing about an actual cure and not just new treatment options.  Don’t get me wrong, I am glad new treatment options are becoming available to help us for now, but curing Herpes Simplex, the most successful virus should be a top priority.  Revenues of such a cure can be re-invested to go after HIV, or other deadly disease.  That would be a great resource of revenue since there are so many infected with HSV and the hope of curing viral infection can also spur more investment in that area. Funding going toward Genital Herpes would also be freed up.  Even the global economy would benefit from a cure.  HSV is not the only Herpes virus affecting humans.  CMV is another dangerous virus that many do not know about.  It can cause severe birth defects and there is not enough awareness for woman who could become exposed to it such as day care workers.  1 in 150 children are born with CMV and 1 of 750 of them has severe birth defects.  CMV is also a major culprit in causing complications for immune compromised patients.  Once you have cured HSV, CMV will be easy to cure.  There is other type of herpes virus that affects other species; even coral reefs can suffer from a herpes viral infection.  The Genital Herpes community could make a huge impact in not only their own lives but help the lives of so many others by supporting researchers who are trying to bring about a cure.  They can even help with the impacts of other herpes virus in other species.  With that said, we can make a huge impact on our planet.  A very positive impact.  We cannot count on current philanthropist and what they feel is the right way to go.  For example, Sangamo Biosciences is working on a very encouraging product using ZFN technology to treat HIV.  I recently noticed that the Bill and Melinda Gates foundation donated 100k to help.  It’s not that I don’t appreciate what they are trying to do, however 100k is pocket change to these people.  It’s all about prevention for them and other organizations like them through microbicides and vaccines.  Since when is a cure not prevention?  So, for the STD community, we really need to step up when it comes to funding actual cure research.


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by Terri Warren, RN, Adult Nurse PractitionerBlank, Sep 09, 2012
Perhaps you are confused about what AiCuris study we are doing:  It is a phase 2 trial, not a phase 3.  

Lynn 9973, I would strongly suggest that you get a culture done of one of your outbreaks and have it sent for resistance testing through Quest labs.  I don't know where you live, but I honestly think it would be worth doing.  Since you have frequent recurrences, this should be fairly straightforward.  

The research suggests that 0.3 percent of strains of HSV 2 are resistant to drugs like acyclovir.  Half of those are in people who have taken medicine and half in people who have never taken medicine so thankfully, it doesn't appear that at this time, drug acquired resistance is really an issue.  I'm sorry that you are really struggling with this though, it has to be difficult.

Along those lines, I would like to tell you that we have seen several people in our clinic, some who have come from quite a ways away, who believe that they have drug resistant disease.  They continue to have what they believe are numerous recurrences.  And to look at their genital area, I would have agreed.  But upon testing, what they have is often not herpes but other conditions that mimic herpes.  Bacterial infections are common with genital ulceration.  

When I teach medical students and NP students about herpes, I always remind them that not everything that happens in the genital area of herpes IS herpes.  When resistance is suspected, resistance testing should be completed in every possible case to be certain that is what is going on.  For example, I saw a woman who had been on 2 grams of valacyclovir for a full year without response.  Her labia looked so painful with multiple ulcers.  Her doctor was at her wits end.   The woman was indeed positive for HSV 2, but her ulcers were from a bacterial infection, not HSV 2.  Within 2 weeks, her labia looked normal for the first time in two years.  Not everyone has such remarkable outcomes, but it is a story worth thinking about.  

Smart7, I'm pleased that you responded and have so much interest in the HSV area, we need people like you.

Terri

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by Smart7, Sep 09, 2012
Thanks Terri.  I guess I am confused.  I didn't know that you are doing a different study than the AiCuris phase III.  Guess I should have taken a look before I opened my mouth.  Lol.  I have been advocating for cure research for a while now.  It's really tough because the herpes community is so divided.  I have been verbally attacked but then have others stand up for me.  I try my best to be diplomatic about it because fighting about it isn’t helping on any level.  For so many, it really is just a little skin condition to them.  But for people who struggle like Lynn and others, it’s not just a little skin condition.  I sure can understand the perspective of those who are more passionate about awareness and fighting the stigma.  Although I don’t believe the stigma will ever go away.  I just agree to disagree but I will still stand by them.  I see it as trying to build a bridge in the community.  For those who are bitter to people who only see it as a little skin condition, I hope to help them understand that view and maybe help them not feel so bitter.  This way we can come together and really make a difference for all of us.  It’s not easy.  There are those who have the conspiracy theories like the FDA would never allow a cure.  Then talk about how much money the pharmaceutical companies would lose by curing and not treating.  Currently all antiviral treatments on the market can be bought as a generic, so the big pharmaceuticals are not making the revenue they once were.  A cure for the most successful virus would be a huge money maker for the short term and in the state of this economy, it would be a much needed lift for any company that could produce a cure and get it on the market.  Plus, there are plenty of things to make money on treating.  I mean, there are drugs approved to help you grow longer eyelashes for goodness sake.  What I really like about ZFN technology is not just the fact that it is the future of medicine, but using that technology, or mega nuclease technology to cure viral infection are stepping stones to curing all types of illnesses.  Not just viral but genetic dysfunctions and such.  Sorry for going on and on but this is something I have wanted to say to the GH community and healthcare providers for a long time.  It’s so nice to hear that you agree.

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by Ms_Hurt, Sep 20, 2012
Hi terri i been diagnosed with hsv1 since the age of 16 i am n22. The first couple of years i was on suppressive therapy but when i became pregnant wit my now 3 year old son my docter boost my valtrex to 1 gram twice a day beacause my outbreaks became more frequent, now my out breaks are out of control i get bumps on my breast under my breast between my legs and really bad on my buttocks i am so torn i cant stop squeezin them its like physcalogical or something the medication seemed to stop working when i had my son ike i dnt have a normal life my whole body is is scared from mini ulcers from sores all over my stomach too should i see a nuroligist?


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by Ms_Hurt, Sep 20, 2012
Im sorry typo hsv2 not hsv1*

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by magoogoo, Oct 22, 2012
Im open to all experimental trials to try to cure this frustrating disease.

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Oct 22, 2012
There are research sites in Seattle, Portland, Galveston, Houston and Indianapolis for these particular studies if you are interested.

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Oct 22, 2012
Also, there is no phase three trial for AiCuris yet.

MsHurt, you need to have these spots swab tested for herpes.  I seriously doubt that's what they are all, given your description

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by angelic1414, Oct 23, 2012
I hope the people in asia aware of this...Hope there's something to cure this disease In medical method. I found some traditional method with herbal and propolis. Still not sure if it works. I'm trying to consume propolis. Wish me luck

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by Auhelpme2, Nov 19, 2012
Hello, this is the first time I am reaching out on a forum. I've been diagnosed with hsv1 less than a week ago, but on my genital area. Are the studies you are talking about going to help someone like me? I feel so hopeless and sad and am worried I will never be the same.

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by beau66, Nov 23, 2012
Terri Thank you so much for being so supportive.   Are there any studies for the cure of oral HSV1 near Atlanta, GA?

What can we do to draw more attention and money to the cure?  Can we partition the government to try and obtain government funding?  

Thank you again
for all your advice..

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by beau66, Nov 23, 2012
Its me again Terri sorry i meant GENITAL HSV1 not oral...

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by beau66, Nov 26, 2012
dd

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Nov 27, 2012
There are no research sites in Atlanta for the studies that we are doing right now, no.

Terri

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by favoured1, Nov 28, 2012
Terri,
I recently visited the doctor because i thought i had a yeast infection and she said i could have herpes and blood was drawn meanwhile i got the antiviral,antibiotics and tablets to treat candida after a week i called back and she said that ihad past exposure so positive herpes but also tested positive on bacterial yeast and got antibiotics again for that i have not had a partner for 4 years do you think i should seek a second opinion interms of testing..oh i feel bad never expected this to happen

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Nov 29, 2012
I'm so sorry, but this really isn't the place to post questions like this one.  You can use the main MedHelp location for questions, though.  that way specific individual needs can be met, this is really just a post about research that is going on.

Terri

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by beau66, Dec 12, 2012
Hi Terri,


I Have genital HSV1 and am curius if you think any of the three studies  being conducted for HSV2 by AiCuris, Agenus, and Genocea will work for HSV1 genitally.  

and Since HSV1 genital herpies is on the rise have you heard of any specific studies that may be starting for that?   I would like to participate in a clinical trial.

Thank you and have
a Good Day...

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Dec 13, 2012
I think what ever works for HSV 2 will also work for HSV 1.

Terri

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by beau66, Dec 17, 2012
Thank you for your response Terri.  

  Is there anyway to persuade AiCuris, Agenus, or Genocea to include
HSV1 infected people as well as HSV2?  

Im sure they know of the current rise in HSV1 genitally.

Thanks and have a
Merry Christmas.

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by Confused70785, Dec 24, 2012
I think it's awesome that there really is a big push for HSV research. It is way overdue and hopefully something will come from these trials. However, what I still can not understand is why some research that is very promising is being left in the dark. These vaccines and therapeutic vaccines I agree are very important and will indeed make a huge impact on lives but what about a cure? The research being performed by Duke University is an actual cure with promise. And since 2008 when they published their huge findings there is not much talk about them. Yet they are still getting funded to move forward so there is some interest however, they are way underfunded. Why is this? And what's even more impressive is the drugs intended to be used by their research are already on the market! Obviously modifications would be needed to the drugs but the platform is there. I know for me I should would like to know I'm cured rather than knowing that I still have a virus in me that is not suppose to become active because of a shot I received. Terri any thoughts on this? Have you looked into Dukes research? Why does it seem they are being over looked and not making news headlines and able to receive the funding they need. I would suspect that researchers and medical experts like yourself would be extremely intrigued with the possibility of a cure yet since the discovery 5 years ago nothing has seemed to change.

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Dec 24, 2012
There is an entire network of things that happen under the radar - grant funding, peer comments, peer thoughts, things that you and mostly not even I aren't part off.  Anything like the Duke research has a lot of work to do in basic science and animal studies before it even begins to move into humans.  This is a long ways off.  I do know about this research, and it, like every other study in the herpes world, has to move through the appropriate steps for safety and efficacy.  It can be stopped any where along the way for lack of either.  This is way more complicated than you might imagine.  But if you are really interested in this project, there are ways for you to send contributions as well as the University pursuing avenues for funding.  

Terri

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by needcure144, Jan 04, 2013
I recently found out that I have HSV2 after being misdiagnosed with a UTI.  My boyfriend cheated...I am at my wit's end.  Ive had two outbreaks, none since I was diagnosed in November and started taking valtrex.  Im so tired of taking medicine every day.  I just want this virus out of me so I can be normal again.  I find myself looking at the last picture I took before I contracted the virus and I cry...a cure is greatly needed

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by StayingUpbeat, Jan 23, 2013
Terri,
  In a recent presentation to investors Vical's CEO claimed that they have partnered with the University of Washington's virology lab and are going to start a phase 1/2a clinical trial of their therapeutic vaccine in early 2013:

http://seekingalpha.com/article/1106371-vical-s-ceo-presents-at-31st-annual-j-p-morgan-healthcare-conference-transcript?page=6

Have you heard anything about this? Would Westover be one of the testing sites?

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Jan 24, 2013
Hard to say, but I would hope so!

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by jxkchicago, Jan 28, 2013
I was recently admitted into aic316 study and am thrilled. When inquiring about timing for phase lll, physician was uncertain. Regardless, the possibility of complete supresion is a giant leap forward.

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by jxkchicago, Jan 30, 2013
Terri - have heard of any discusion of the possibility that a course of treatmrnt of aic316 could allow the immune system to rid one of hsv?

Thanks in advance

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by originalsbyterry, Feb 03, 2013
Dear Terri,

Just found this site and am encouraged about the possibilities of effective treatment for Herpes.  I have had type 1 all my life and contracted type 2 about 15 years ago. I mostly use home remedies for ailments and I have found something which alleviates the discomfort of both type 1 and type 2.  It is Chapstick medicated lip balm (the Rite Aid brand is the same thing).  If I feel the onset of an outbreak and begin using it frequently and immediately, in most cases the blisters do not form. I do not know if this would work for everyone, but it works for me.  I would like to share this information with other sufferers.

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Feb 04, 2013
I have not heard about when a phase three AiCuris study might happen. And I've certainly not heard anything about treatment with pretilovir allowing the immune system to rid itself of herpes.  I don't think that is a feasible suggestion at all.

Terri

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by SwanStar, Mar 09, 2013
Dear Terri, I hope you read this.

I read your book 'Good News About Bad News' in Google books but the whole book was not available there but I think you have missed something very important.

Let's say that 90% of certain population has HSV-1. And let's say that we use an antibody test that gives only 5% false negatives. To keep this example simple, let's also presume that test does not give any false positives. Now, we test million people of the population where 900 000 people have HSV-1 and 100 000 does not have. Now all the 100 000 HSV-1 negative people tests negative. Of those 900 000 positive people 45 000 gives negative test result! That means that almost ONE THIRD of all the negative results are FALSE NEGATIVES.

This same inference goes for HVS-2 too. If some population have 10% prevalence of HSV-2 and if we presume that a certain antibody test gives 5% false positives, then again we have that one third of all positive test result are false positives.

Unfortunately I haven't managed to find out what causes  false positives or false negatives. Could the number of false negatives be diminished by taking an antibody test several times? I have tried to ask this from several doctors but their answers have been quite general. I am not sure if they even understood what the problem was.

I would be very thankful if you help me with this.


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by Terri Warren, RN, Adult Nurse PractitionerBlank, Mar 09, 2013
I'm not following your math.  But I can tell you how the statistics are arrived upon.

Of 100 people who test positive for HSV 2  by swab test (there were thousands, not 100), 97 of them test positive for HSV 2 antibody on the test.  This gives the sensitivity of the test.  16% of the population has HSV 2

Of 100 people who test positive for HSV 1 by swab test (again, thousands participated), 91 of them test positive for HSV 1 by antibody test.  56% of the population has HSV 1.

Terri

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by SwanStar, Mar 12, 2013
Thank you answering Terri.

I try to explain again and better. Sorry about my English. It is not my native language.

Let's say that we know somehow (by swab tests) that in a certain population 99% of people have HSV-1 (for example people in morocco, source:http://en.wikipedia.org/wiki/Epidemiology_of_herpes_simplex). Then, of million people in this population, 990 000 have HSV-1 (because 99% of million is 990 000) and they should test positive and 10 000 do not have HSV-1 and they should test negative. Right? Now if we test million people in this population, we have following test results (let's presume that the sentivity of the test is 97%):

- 10 000 negative antibody test result and they do not have HSV-1
- 960300 positive tests and they have HSV-1 ( because 97% of 990 000 is 960 300)
- 29 700 negative test results even though a person has a HSV-1 (because 3% of 990 000 is 29 700)

So we had altogether 10 000 + 29 700 = 39 700 negative results but almost 75% of them are false negatives (because 29 700 of 39 700 is 75% ).
This means that if we test a randomly selected person from this population and we get negative result, the result is incorrect by probability 75%. Not 3%. This is due the fact that even though a test has very high sensitivity, it gives a very large number of false negatives because HSV-1 is so common in the population.

So, to make a correct estimation of how likely it is that a random person has herpes depends not only on their test result but also on what is prevalence of herpes in their population. I think this is very important to understand because if a person belongs to a population where herpes is very common, antibody test is almost useless. However, it would be useful to know why some people give false negative and is there a way to improve the sensitivity of the antibody tests.

This same calculation applies for HSV-2 too but because it HSV-2 relatively rare, test gives high amount false positives which may mean that a persons who is in a relationship with a person who has a genital herpes, may discard all the safety measures because they believe that they already have a herpes. Very unfortunate situation.




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by ckarns01, Mar 13, 2013
hi terri i dont know how this works and i wanted to ask you a question about this disease but i cant figure out how to post on your page can you please contact me regarding the question i have

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Mar 13, 2013
Questions about individual situations can be posted on my board on MedHelp.

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by lozza2013, Mar 14, 2013
Hi Terri could you tell me a little more about what's happening with getting a cure for hsv2. It's messing up my world in a big way and hoping a cure will be soon
Thanks

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by lozza2013, Mar 14, 2013
Hi Terri could you tell me a little more about what's happening with getting a cure for hsv2. It's messing up my world in a big way and hoping a cure will be soon
Thanks

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Mar 14, 2013
There are no cures for herpes on the horizon right now

Terri

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by jxkchicago, Mar 22, 2013
Hi Terri - just an update on aic316 phase llb trial I am enrolled in. I started the second arm and without question it has to be pritelivir. After only 3 days into the second arm, I have no symtems of hsv, no redness or tingling which were daily occurences.

Pritelivir is definately superior to valtrex!

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by hollydollyholly, Apr 23, 2013
Is the pritelivir suppose to permanently suppress HSV/cure it or is it just an updated form of a daily drug?

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Apr 24, 2013
It is, we hope, a better drug to suppress shedding than we have now.

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by hollydollyholly, Apr 24, 2013
Prob a good stock to buy considering their phase trial results...

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by ce3016, May 07, 2013
Terri,

I live in the Houston area.  How can I volunteer for the Phase II research here?  I want to help in any way that I can!

Also, are there any updates regarding the research for the HSV-2 cure?

Thanks...

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by Terri Warren, RN, Adult Nurse PractitionerBlank, May 07, 2013
I think all the studies are closed for enrollment now.  They just closed last Friday.  Sorry about that!  There is a research site in Houston, Dr. Steve Tyring.

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by StayingUpbeat, May 15, 2013
There are reports that the AIC-316 trial has been suspended. Is this true? Did they give a reason?

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by Terri Warren, RN, Adult Nurse PractitionerBlank, May 15, 2013
AiCuris has put the trial on hold to further evaluate findings in animals and discuss those findings with FDA. Over 80 subjects have been enrolled and over 40 have already completed the study treatment.  To date, there have been no unexpected or serious concerns about safety in this trial.  To be cautious, all subjects have been asked to stop any further treatment until the FDA completes their data review.  

I know this must be disappointing for people with herpes all around the country.  But we don't know what will come next so it could restart.  

As the investigator at my site, I know I too am disappointed.  Nothing, however, trumps subject safety.

Terri

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by jxkchicago, May 18, 2013
Hello Terri - being 1 of 40 to complete the study I can not begin to describe my disapointment with fda suspending the study. Pritelivir is definitely superior to valtrex as I experienced it. My only side effects were dry skin and slight stomach aches. My understanding is monkeys developed enimia and possibly some other effects but at much greater doses.

Being non cancerous one would think fda would weigh risk to benefit and allow the the study to continue since dosage is tiny compared to what they feed monkeys. But the fda being the patient's worst enemy has essentially killed the study.

Aicuris needs to find a partner to start phase lll instead of trying to find the highest bidder for the company. Without big pharma to push its weight against fda's incompetence and corruption, pritelivir may be dead to the delight of gsk, valtrex's manufacturer.

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by SubversiveKnight, May 20, 2013
Hi Terri,

I am from Australia. Can I add that there is an Australian Company also about to commence a phase 1 trial I think in to preventing and (hopefully) curing herpes.

http://www.coridon.com/page/current_development_program.html

There is some real hope here as the person running the show is the same person who discovered and facilitated the vaccine for some strains of HPV (Genital Warts). I think it's called Gardisal.

See:

Prof. Ian H Frazer FAA FRCP(Ed), FRCPA, Chair and Non-executive Director

Professor Ian Frazer is a clinician and pathologist, trained in immunology at Edinburgh University and the Walter and Eliza Hall institute in Melbourne. His accomplishments include a 15-year track record of world-class research in viral immunology and vaccine development. He has a portfolio of eight completed patents. He has collaborated over 13 years with CSL Ltd and Merck & Co to commercialize a cervical cancer prophylactic vaccine, and to develop therapeutic vaccines for HPV infection. He was the first to identify the HPV L1 protein as a vaccine candidate. In 1999 he won an Australian Biotechnology Award for successful collaborative research leading to product commercialization. In 2004 he was inducted into the prestigious Australian Academy of Sciences in recognition of the significant contribution he has made to biomedical science.

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by Terri Warren, RN, Adult Nurse PractitionerBlank, May 20, 2013
Ian Frazer is definitely a highly regarded name here as well.  Very exciting stuff!

Terri

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by jxkchicago, Jun 19, 2013
Terri - I see aic316 trial has been terminated, does it mean no further trials?

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Jun 19, 2013
We just don't know that yet.  

Terri

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by seja666, Jul 25, 2013
Do you think in the next 5 years there will be something solid to rid of herpes 2 for good? Looking for some hope- diagnosed this week :(

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by StayingUpbeat, Sep 09, 2013
I noticed that Genocea recently posted that they are going to be presenting positive interim results of their Phase 1/2a trial at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013) on September 12. Aside from the fact that it is apparently good news do you know anything about the results?

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by alwaysadvocating, Sep 15, 2013
Nurse Warren,

I am writing to thank you for providing such clear and detailed information on the herpes virus. For years, i've been worried about whether or not I had contracted it in the past. I have had several blood tests that were negative, but was still worried about having false negative results, outdated tests, and if I had received the best test designed to accurately detect the virus. After several tests, consultations with doctors, and searching for solid information via the internet (confusing/conflicting information), I came across your work. It wasn't intimidating or overly technical. Once I read it, I immediately felt assured and positive that I did not have herpes once and for all. The entire book was very helpful and easy to understand. Thank you so very much! You have truly set me free!

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Sep 16, 2013
Oh wow, I'm pleased.  That's great news.  I'm glad you feel reassured.

Terri

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by jwow15, Oct 09, 2013
Any trials available in the Washington, DC area? I'd be interested in participating.

Thanks

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Oct 09, 2013
None that I am aware of

Terri

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by Manyhopes, Oct 10, 2013
Hi terry, I was diagnosed with hsv 2, a few years ago and it has affected my life. My question is how far away u truly think they are away from a cure?  Every 2 weeks I donate money for herpes research. All of us who is affected should donate, as this could speed up the research cure.  I pray for the day we can all celebrate Sincerely affected

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Oct 10, 2013
I honestly don't think a cure is close, but effective treatments are close.  The therapeutic vaccines look very promising, and perhaps, in combination with oral therapies. we can get viral shedding numbers to be very very low.  
I'm hopeful that we will also be starting a study soon of a new antibody test that helps clarify the diagnosis for many people who initially have a low positive ELISA.  
We are also working on getting a study funded to evaluate the real effectiveness or lack thereof of IgM antibody, which you all know I find very difficult.  I think we will try it through a crowdfunding site.  

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by Q5050, Oct 22, 2013
Hi Terry, I was just wondering, who do we call about joining into one of these studies? And is it too late to join?

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by Q5050, Oct 22, 2013
Terri*... Very Sorry


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by Terri Warren, RN, Adult Nurse PractitionerBlank, Oct 22, 2013
I would look on clinicaltrials.gov.

Terri

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by StayingUpbeat, Oct 31, 2013
I'm not sure if Jwow15 is still checking this page but there is a clinical trial, sponsored by Sanofi Pasture and the National Institute of Health, in the DC area for an HSV vaccine/therazine for people who are negative for HSV2 or positive for both HSV1 & 2.

http://clinicaltrials.gov/ct2/show/NCT01915212?term=HSV&recr=Open&rank=7

It's called HSV-529 in the trial but I believe it was originally ACAM-529 before Sanofi bought Acambis. If so it is a vaccine licensed from Dr. David Knipe (virologist at Harvard) and is the first live attenuated vaccine that has been tested in humans for a long time.   Maybe Terry knows?

Dr. William Halford (another HSV vaccine researcher) gives a pretty good description of the differences between it and the other vaccines in trials (again assuming its ACAM-529 renamed):
http://herpesvaccine.scienceblog.com/2013/09/15/de-risking-hsv-2-vaccine-development/

The NIH has an online application and questionnaire for anyone interested in getting involved with the trial here:
http://www.niaid.nih.gov/volunteer/hsv529/Pages/default.aspx

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by lotus1973, Oct 31, 2013
RESULTS OF HSV2 IGG 5.187....HSVI IGG 3.525
I KNEW I HAD HSVI BECAUSE OF COLD SORES ON MY LIPS BUT NO IDEA OF HSV2!!!!
STARTED GOING OUT WITH THIS GUY WHO LATER TOLD ME HE DID NOT USE CONDOMS WITH HIS EX PARTNERS!! WHEN I ASKED TO GET TESTED HE SPECIFICALLY ASKED  IF THEY TESTED FOR HERPES...THEY DID NOT....LATER I GOT TEST AND THAT WAS MY COUNT... I NEEED TO KNOW IF I GOT IT FROM HIM OR DID I ALREADY HAVE IT BASED ON THE IGG COUNT? HOW CAN I FIND OUT DESPERATE PLEASE HELP!

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Oct 31, 2013
This is not a place to answer personal questions, sorry.  You can post questions at MedHelp

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by lotus1973, Nov 01, 2013
I though I had my apology, will figure how to do that.

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by lotus1973, Nov 01, 2013
unless you'd like to share how I should do that...

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Nov 01, 2013
You can go to MedHelp and look for the herpes board and post there.  

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by norainbow, Nov 20, 2013
I recently contracted HSV2 while using a condom (pubic area) and have since been on Valtrex to keep it under control.  I'm very optimistic about the research going on right now by numerous companies to find a  therapeutic vaccine for HSV2. It sounds like between 2017 and 2019 there will be something on the market in the form of a theraputic vaccine for HSV2 ,so hang in there everyone.

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by StayingUpbeat, Nov 23, 2013
Ms. Warren,
  I recently noticed that a Phase III trial was started for ASP2151 (Amenamevir) for both Herpes Simplex: http://clinicaltrials.gov/ct2/show/NCT01959295 and Zoster: http://clinicaltrials.gov/ct2/show/NCT01959841. Do you have any insight into this trial?  
  I've also never seen a trial "by invitation only" is this specific to clinical trials with Japanese companies or Maruho Co. limiting the drug to patients they are treating?

Thanks!

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Nov 23, 2013
to stayingupbeat, I don't see that trial at clinical trial.gov with the link that you sent.  Can you recheck?

I wanted to let you all know about study we are trying to conduct to evaluate the accuracy for the IgM test for diagnosing new or any genital herpes infection.  It has been our experience that the IgM antibody test has many false positive results as compared to the IgG ELISA test (the routine screening test) or the herpes western blot.  There are no funds readily available to conduct this study, but we do feel it is very important as many people have been told herpes, based on this test, who do not.  As a result, we are trying a novel concept, using crowdfunding to attempt to fund a research study.  For more information, or to contribute to the project, please visit  http://www.rockethub.com/projects/35608-fund-a-study-to-get-rid-of-bad-herpes-tests

Thank you in advance.

Terri Warren

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by Ernest73, Nov 24, 2013
a 100% cure in how many years terri....
10yrs 50 yrs....atleast 100 yrs...

just give an informal guess...
for curiosity's sake!!

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Nov 24, 2013
oh goodness ravi, I have no idea.  Wish I did!

Terri

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by Terri Warren, RN, Adult Nurse PractitionerBlank, Nov 24, 2013
To StayingUpBeat,

Thank you so very much for your contribution to our IgM study.  You are the very first contributor and I'm so hoping this is going to work!  Yippee!

Terri

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by StayingUpbeat, Nov 24, 2013
Just donated $100. Thank you for this effort and everything else you do!

Maybe I'm not entering the links correctly.  The ASP2151 HSV trial can be found at clinicaltrials.gov with identifier: NCT01959295 .  The Zoster trial is under clinicaltrials.gov identifier: NCT01959841


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by LittleOne73, Jan 12, 2014
Hello Terri,

I cant read through every single comment, so Im hoping you can help me. I was wondering if there is any hope for some cure for HSV? I am going through a lot right now, for I was honest with someone, they understood and now he is freaking out, out of the fear of it. Which is making me horribly worry. I got this almost 16 yrs ao and through all my long term relationships have never given it to anyone. I never get outbreaks but Im still so scared. He says he has a small bump on his scrotum now that is a tad bothersome. I know the first one is usually really uncomfortable and is usually in clusters not just a single bump. He went to get tested about 2 weeks ago and says he didnt understand the results but the doctor never called him. Does a first outbreak on a men usually start that way? And if it was positive wouldnt they call him?

Im so worried now.
Lisa

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by jayfreemas, Feb 11, 2014
What is funny is these crappy american ******, dont want to give us human beings a cure. Because its just like the car companies.Imagine a Chrysler 300 made of nothing but stainless steal, and there top of the line, most advanced engine components. Ok now you have a car that will last for almost as long as you live. Chrysler then goes bankrupt. The pharmaceutical industry is the same people. They should be hung on an upside down cross, stabbed and then burned. After completely mutilating their genitalia. THE ONE GUY THAT IS THE REALIST OF THE REAL IS     ~*(DR. IAN FRAZER)*~     look him up people and prey for the fda to not screw us all again.

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by jayfreemas, Feb 11, 2014
DR. IAN FRAZER experimenting with the vaccine for hsv2. That has worked in all animal testing and passed the first stage of human trials. He also came up with Gardasil the hpv vaccine. I hope this man accomplishes his goal. Im not you all but im a 23 yr old male from ohio and i hate my life because of this. But this guy gives me a lot of hope. Lonely is the person who suffers from this virus

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by san101, Feb 16, 2014
Hi Terry,

I had a bad yeast infection back in November 2012. I got some sores also on my penis gland. My doctor thought that I am having HSV 1/2. He ordered a blood test (igg). Both came back negative  for HSV 1 and 2. Then he gave me fluconazole for the yeast infection and it healed me. Then last year November (2013), I had similar symptoms on my penis gland and under the foreskin. I got fluconazole from the doctor for the yeast infection, but it did not go away completely (It healed and came back several times). Both times, doctor asked me to use an antibiotic cream (mupirocin/bactroban). I used it since Nov. 2013 to Feb. 2014. The cream kind of controlled the condition (I do not know I overused it). Then I went to see my dermatologist Feb. 7 2014. He again suspected my symptoms as HSV 1/2 and ordered me to do a blood test and prescribed me valtrex for five days. But, I did not take valtrex until I hear the results from the blood test. I only used a topical cream that my dermatologist gave me on that day (Alcortin A). With the use of topical cream (for 4 days) it healed me up before I heard about the results from the blood test (igg). This time it came back positive for hsv 1 (1.65) for HSV 1 (may be genital hsv 1 because I had complications in penis (on gland and under the foreskin). HSV 2 was still negative. Then the nurse called me and asked me to use valtrex as prescribed for five days. I am so frustrated with the result.

I cannot believe it. I did not have any symptoms for HSV. My wife did not have any symptoms to HSV all this time. Could this be a false positive (igg value of 1.65)? I am planning to request a Western Blot test soon.
Could someone please explain this to me. I really appreciate it.
Thanks a lot.

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by san101, Feb 16, 2014
Hello Terri,

I had a bad yeast infection back in November 2012. I got some sores also on my penis gland. My doctor thought that I am having HSV 1/2. He ordered a blood test (igg). Both came back negative  for HSV 1 and 2. Then he gave me fluconazole for the yeast infection and it healed me. Then last year November (2013), I had similar symptoms on my penis gland and under the foreskin. I got fluconazole from the doctor for the yeast infection, but it did not go away completely (It healed and came back several times). Both times, doctor asked me to use an antibiotic cream (mupirocin/bactroban). I used it since Nov. 2013 to Feb. 2014. The cream kind of controlled the condition (I do not know I overused it). Then I went to see my dermatologist Feb. 7 2014. He again suspected my symptoms as HSV 1/2 and ordered me to do a blood test and prescribed me valtrex for five days. But, I did not take valtrex until I hear the results from the blood test. I only used a topical cream that my dermatologist gave me on that day (Alcortin A). With the use of topical cream (for 4 days) it healed me up before I heard about the results from the blood test (igg). This time it came back positive for hsv 1 (1.65) for HSV 1 [may be genital hsv 1 because I had complications in penis (on gland and under the foreskin]. HSV 2 was still negative. Then the nurse called me and asked me to use valtrex as prescribed for five days. I am so frustrated with the result.

I cannot believe it. I did not have any symptoms for HSV. My wife did not have any symptoms to HSV all this time. Could this be a false positive (igg value of 1.65)? I am planning to request a Western Blot test soon.
Could someone please explain this to me. I really appreciate it.
Thanks a lot.


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by Terri Warren, RN, Adult Nurse PractitionerBlank, Feb 16, 2014
This is not a place to answer individual questions, I'm so sorry.  However, very briefly, I will say that you are right on track getting a western blot.  I won't post further comments here about individual situations, sorry about that!  You can post individual questions on the MedHelp herpes board.

Terri

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by san101, Feb 16, 2014
Hi Terri,
Thanks for your reply. I really appreciate it. I have already posted this on MedHelp herpes board. Could you please answer me there. Thanks a lot.

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by Juli1982, Mar 05, 2014
Hi Terri,

I live in Colombia and i have been reading about the medice of AiCuris Laboratory. I would like to try with this drug. where I could to get the "Pritelivir"? I have been suffering the HSV-2 since 8 years ago and I want to try this new medicine.

Thank you so much

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by Sakura_Pumpkin, Mar 10, 2014
Hi terri,

I have asked a question in the forum. but you seem to have a better grasp of herpes, and it seems a non-doctor/nurse answered me. Is it alright to ask you here?

thanks.

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