Jun 04, 2009
Lou Gehrig's Disease (amyotrophic lateral sclerosis or ALS) can run in families with more than one affected family member, called familial ALS (FALS), but typically strikes at random with no family history, called sporadic ALS (SALS). FALS and SALS are clinically similar. However, most people with SALS have symptom onset at about 56 years old, while most people with FALS have symptom onset at about 46 years old.
Sporadic ALS is most likely multifactorial condition, which means that it involves a combination of genetic, lifestyle and environmental factors.
Familial ALS makes up about 10% of total cases of ALS. Different types of FALS are distinguished by their genetic cause, the age at which symptoms began (age of onset), and disease progression (slow or fast). Although 9 types of ALS have currently been identified, only a small percentage of cases have actual known genes and established patterns (modes) of inheritance. As of yet, researchers have only adequately identified and classified genetic mutations that cause ALS types 1, 2, 4, and 8.
For more information on the symptoms of ALS and genetic components of ALS, visit: http://AccessDNA.com/condition/Amyotrophic_Lateral_Sclerosis/35