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| DoubleDose 7/9/2007 | . | I just returned to town yesterday only to read the recent threads regarding occult HCV and HBV issues. Thanks for bringing the 'old board' back to life!!! Good to hear all of you weighing in, and contributing material for the forum. Now, as you all know, I have pretty adament opinions on HCV occult, and persistent viral behaviors. Of course my more radical suppositions are still very un-researched, and generally met with skepticism.....BUT each new research article on Persistence after SVR, and after spontaneous clearance, only lends more strength to my concerns. I begin to see a potential cause for all the Post-SVR problems, that may go beyond Interferon hangover, and damage from tx. I think that the odd, infectious state that may exist after SVR, might well be responsible for many of our long term woes. I still believe that the virus does much more within our bodies than currently understood by mainstream HCV experts. I suspect that Central Nervous System issues, and infection are probably a reality, as well as the Lymphoid, connective tissue, and possibly Brain cell structures as well. Whether lingering, low level virus causes actual damage in these organs, or causes an 'auto-immune' response is open to question...but I really believe there is something going on....in the SVR population. Maybe the 'liver/ blood' virus, is really a multi-faceted, multi-system infection, that only becomes highly visible, and detectable, when it overcomes the immune barriers, and becomes a chronic, and/or acute blood infection. Thus IVDU's are the most 'visible' group, and generally have the full bore infection! I still strongly suspect other modes of infection, and transmission, that are NOT the typical, detectable 'Blood/ Liver' types of infection. If the virus can live, and reproduce in Lymphatic, Salivary, connective, and nerve tissue, then there is no reason it cannot be transmitted directly from these to similar tissues in others. It may just not become, nor provoke, a 'typical HCV blood infection', in those persons. Possibly sexual tissues, and gastric tissues could also become infected, and set up silent, undetected low level states of reproduction, causing vague digestive, and reproductive problems. All undetected by typical HCV testing. I know this is somewhat of a stretch from the straight information the research studies have provided, but there is a LOGIC to what I am stating. And it all follows the findings of the research lately. I would love to hear some discussion on these theories. I will accept the criticism as well, in advance! Just my individual take on what might be going on. I still can swear that I see odd symptoms in intimate contacts from over the years. Much like CFS, or CFIDS. All these contacts are 'undetected' for the typical blood HCV antibodies. But now, I have more ammunition for why this might be so. Maybe the infection is cellular, and localized. Maybe it is held 'in-check' like SVR's. It might cause NO antibody reaction whatsoever in the blood, but might cause lots of symptoms. (and provoke lots of immune system reactions) Best wishes to all, and hopes that you are all well, and enjoying the holiday! Let's hear the hooting! DoubleDose |
| copyman 7/9/2007 C1 | DoubleDose | you bring up some good points and anything is possible with this disease. but speaking for myself i have to much other stuff to worry about then to dwell on this. i would be very happy to become svr as they call it and take my chances with the occult thing. i hope to see a pcr with <5 on the results someday, hopefully without to much damage done to me by the tx drugs.. |
| jboyhk 7/9/2007 C2 | . | The one proof would be if someone discovers that the HCV virus emits a detectable antigen when replicating as HBV does. In HBV, the inactive carrier state has undetectable viral load in the blood, but we know it is still presnet since we can detect a specific antigen in the blood that is produced when the HBV replicates. Many inactive carriers still feel like something is not right with their system. The good news is that , medically speaking, in this situation (just like the SVR HCV situation) , the potential health risks are dramatically reduced. |
| DoubleDose 7/10/2007 C3 | To Everyone ! | Hey, I threw out the line and hook on this one, but not many takers. I'm going to have to move my boat if I can't get more fish action than this!!! I had already put my hardhat on to avoid the rocks, but no need I guess. Comments, as always, are welcomed......good, bad, or ugly! DoubleDose |
| frijole 7/10/2007 C4 | DD | Don't give up. I read your thread this morning and then it disappeared. It is about 8pm here now and this is the first time I have seen it again. It is not a problem with my personal setting (which I just discoverd today along with how to put a profile in (it is at the very far right of the MH screen and actually I have to scroll to get there)). So I think your thread disappeared and resurfaced. It is a MH problem. Please keep bringing up these issues. I have been paying a lot more attention to Hepatitis B issues too since the thread about occult Hep B a few days ago. When I finally located my hep B test, I fall right into that category -- negative for the antigen (HBsAg) and postive for the antibody (Hep B Core Ab)--of people who are more likely not to clear Hepatitis C with treatment. My Hpe B Surface Ab is <3.0 mIU/mL --"inconsistent with Immunity." So this may have factored into my relapse. So, let's keep these discussions about occult virus alive and well Be well, frijole |
| DoubleDose 7/14/2007 C5 | Posts have been moved. Where are the old posts? | I can't seem to find any of the old posts on the new format. | [Thread closed to new comments] |
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