"asma asna anti lkm and other and also had liver biospy twice show f1 in 2013 and f4 in 2016 but still the liver enzymes is isssues and now doctor restarted my treatment with dna 83 and hbsag 10032 and doctor started tenofovir 25 mg plea..."
in my situation, my hbv dna went undetectable for 3 to 4 years, and then hbsag became negative, then anti-hbag appeared.(finally hbsab out numbered hbsag), my dr. did not let me go immediately after i have developed anti-hbsag, and i was on viread for one more year, then stopped the pill. and check the blood 6 months after stopped the pill to make sure no relapse. there are multiple indicators to tell the virus has been suppressed by my immune system, tiredness gone, more energetic, food taste better, my alt is record low 31 as the liver is healing itself, and all those little headache and muscle ache here and there i thought was normally now all gone, and suddenly everything gotten better.
the hbv blood result normally consist of multiple tests such as alt, ast, hbvdna, hbsag, hbcab, hbsab, etc, and if on medication, some dr also check the kidney, and all these test need to be considered to make a sounding diagnose, can not be based on a single value like anti-hbsag alone. in your particular situation, you maybe near the end of the race, just need a little bit more push, but so far, based on your posted results, your hbsag and hbv dna are low but still positive, therefore, your immune system has not fully able to suppress the hbv yet. if you are not seeing a liver specialist, i would suggest you to get a 2nd opinion from a real GI or liver specialist, some family dr may not have aware of these.
Hi, i am not an expert or doctor,
but from I understand on how the HBV behave, it is a DNA virus, what we can measure now with today's technology is the by-products of the virus, and it exist in multiple forms such as hb surface anti-gen, hb envelope anti-gen, hbv dna, etc, and if your immune system is responding to the virus, it will cause fever or inflammatory to the liver, therefore, elevated ALT.
As stephencastle point out, having anti-hbsag positive means nothing if hbv dna or hbsag is (are) still detected, and the reason for this condition is unknown, my guess is if the hbv virus ever mutated, and your body may have produced the wrong anti-hbsag. this hbv virus will stay inside the body forever due to its cccDNA is rooted and hidden deep inside liver cells.
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