Not certain about the Calms but I do know a lot of parents are trying food supplements which have shown to be helpful, Vit B Complex and Vit C and fish oil also the essential amino acids have shown benefit,as they support production of the Neuro transmitters necessary for optimal brain function. Also try elimainating allergy foods for a while like Dairy and Wheat then add them back.If you put it into your search engine there is a lot of information for Parents wanting to try the "Natural Way" for their children without the tough side effects .Good luck