Oh, not good. The major problem is (according to Dr. Charles Parker in his book "New ADHD Medication Rules", pg. 71& 72) is that Prozac (fluoxotine is the generic) blocks one of the two most important pathways through the liver for stim meds. If the stim med backs up it increases in intensity and can actually "make the patient psychotic on the resulting toxic reaction. This toxicity, with symptoms ranging from feeling jittery to paranoia, is common." In short, the amphetamines accumulate, "with resultant anger, rage, mind racing, sleep deprivation and subsequent lack of control, even associated with paranoia. As I noted above, the mild interactions can look like the medications need adjusting, appearing as if the ADHD has returned full force." Which, of course, can make it even worse.
You might want to print this out and show it to your doctor. Do not under any circumstances suddenly stop Prozax, it has to be tapered off.
Dr. Parker recommends taking Zoloft, Luvox, Celexa, or Lexapro as they are fairly clean. http://www.corepsych.com/2012/09/adhd-insights-prozac-paxil-ampehtamines/
Long story short the interaction between the Prozac and the stim med may be part of the problem. Hope this helps.
I, too, am an adult with ADD. It does take some time to get used to Adderall. If you stick with it for a while you might find that the negative effects that you've described will go away. Or, you might just learn to cope with them better. I had the same side effects after going back on adderall when I was in my early 20's.
Personally, I don't think that Prozac is the problem. I base this non-professional opinion on personal experience. Some ssri's including Prozac have been shown to prolong the effects of Adderall. Thus causing the side effects that Sandman describes. I, personally, never had any of those side effects.
I was on an excruciating treatment for liver disease a few years ago. Consequently, my doctor put me on Prozac while on Adderall. It did calm me down somewhat. He told me that Prozac was the ssri of choice for liver disease patients.
I would try decreasing the dose of Adderall. Most doctors say to experiment with the dose until you find the amount that works best for you. 10 mg can be a lot for some people. That's especially true given the Prozac/Adderall combo. And if you are still having unwanted side effects ask you'r doctor about one of the many other ADD meds on the market.
Hey Kirk. Really good points. I am wondering though if your liver disease changed how the liver normally handles Prozac? If Prozac normally blocks a pathway through the liver which allows the stim med to back up - I am wondering if a liver that is not functioning too well would still work the same way? Certainly agree that trying a lower dose is worth doing.
Hey, I guess a good question would be has the " paranoid & xtreme anxiety" gotten worse lately since you have been on the stim med? Did you have this as soon as you started the stim meds or has it been gradually getting worse - which could indicate an interaction problem.
Oh, by the way, according to Parker, a high protein meal before taking the stim med will make it last much longer and be more effective.
By the way, I don't know if you are on the XR version or the shorter acting version since both come in 20mg's. since the possible duration goes from 4 hours to 10 hours it does make a difference in planning out your day. And, I have heard some people say that they actually sleep better on the meds as it stops their mind from racing. As Kirk says, this may take some trial and error on your part and your doctors. But, I would check into the interaction part of prozac and your med.
Thanks for the feedback guys. Today I took my adderaall regular doses. I had the day off. I went shopping and didn't feel paranoid but I felt socially detached for a while. I did get a terrible nauseous feeling maybe because I had very little food in me. I notice the speedy feeling is a bit less could this be my system getting used to it? I still plan on not taking it at work. I can't risk that feeling of paranoia in the workplace. Thank u all. All feedback is welcome.
I have read that a high protein breakfast (or in case, maybe lunch?) really helps with the way the stim med works. You might want to experiment with that.