I have been on Methadone maintenance for almost 3 years and have abstained from all other drugs and alcohol. I have been experiencing feelings of depression and feeling overwhelmed and would like to try an anti-depressent. I took Paxil, briefly while in College. I had a good result and remember no sexual side effect. Is there a negative reaction when Methadon and Paxil are mixed? Will it show up on a drug screen? If Paxil isn't an anti-depressent I want to consider, is there another one that I should discuss with my physician?