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Addiction: Substance Abuse Community
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Paxil vs. Zoloft

From a patient's perspective what are the meaningful differences between Zoloft and Paxil? I know that they are both SSRI inhibitors and have similar side-effects.  I guess Zoloft stays in your system longer than Paxil.  I have been on Zoloft before for several years off and on, usually between 50 and 100 mgs, but have stopped taking it for about 3 months.  I have not suffered from any withdrawal symptoms.  My anxiety symptoms and associated depression which led me to take Zoloft in the first place persist and have increased in intensity on some episodes.  Zoloft definitely helped me with these symptoms but never completely rid me of them.  I am now considering Paxil since it appears to be more directed to social anxiety disorder which is definitely my core problem.  I have concerns however because I've seen many postings discussing the difficulties of getting off Paxil.  I have not seen such discussions about getting off Zoloft.  Please tell me more about Paxil and whether it is more risky than Zoloft.  Thank you.
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Avatar universal
Hi there. I'm getting off Paxil right now that was prescribed for postpartem depression. It worked great1 But, I'm experiencing terrible withdrawl symptoms. I've even been reducing dosage more gradually than the doctor suggested, because I can hardly stand it. Sever dizziness, nausia, headaches (all everyday, all day) and occassional numbing in hands and feet. Definitely do your research before you make a decision to switch.
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