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info. on rebound pain

My friend is on a pretty high dose of methadone...i told her about the "rebound pain" from actually taking pain pills, how taking pain pills can actually make your pain worse...BUT...i cannot find any information on the internet anywhere...it all refers to rebound headaches...does anyone have any ideas where i can get some "valid" information on this for her...i dont know enough about it to explain it to her in full...  thanks...
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Avatar universal
thanks...i was starting to wonder if it really exsisted, LOL!!!  i kept coming up with rebound headaches in my searches...thanks again...
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Avatar universal
I'm doing so much better.  On 16-20 mg/day.  Doc hasme at 16 so I have to call and tell him it seems 20mg is good.  I'm getting so much done - cleaning, organizing, bills, etc.  I havent felt like giong out too much though so hope that changes.  Get tired once in a while but just for a little while.  Thanks so much for asking.  Hpe all is well with you?  :)
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233181 tn?1235183152
EXCELLENT information. You are right you find more helpful info on Yahoo than on Google when it comes to addiction help and behavior. I know you just started the suboxone. Are you finally adjusting to the med. There is a ton of info on Yahoo under psccmentor.org that does not come up on google. Good Job-------------NOAH
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Avatar universal
opiate-induced hyperalgesia
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Avatar universal
FYI - I foung these and a lot more by searching through yahoo and putting in opiate rebound pain
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Avatar universal
On another site:
In some cases there is also the phenomenon of rebound pain, whereby the wearing off of the drug brings on an exaggerated level of pain which calls for more drug and a negative vicious circle of narcotic use.

This whole scenario was called to mind as a result of the case history of a new friend of mine. He told me how his excruciating back pain from two completely blown out lumbar disks lead to surgery, and then to a life of increasing dependency on Vicodin, a narcotic analgesic not even as strong as the opiates endorsed by the experts in the AARP article.

He was eventually taking huge doses daily, and would wake up with awful pain. Soon the medication seemed to be only marginally effective against the pain, and he became depressed. He basically did not want to live any more.  An antidepressant medication did help him with the depression (unusual for that type of depression), but he told me that if I had advised him to get off the pain medication at that time he definitely would have found another doctor.  Eventually his pain got so bad even on all those meds that he himself decided  he would stop the drugs. That began a month of sheer tortuous physical and mental anguish, but the end result was that he got his life back. His pain diminished greatly and his depression cleared, and he got off the antidepressant. I share this because my friend told me to use his story to help other people that might be suffering from opiate pain killer dependency and the rebound pain phenomenon. He offered to talk to anyone who may be where he was when he wouldn't consider that his pain medication was ruining his life. Just let us know you want to talk to him, and I'll have him give you a call.
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Avatar universal
I just looked it up:
The major discovery is that the classic opioids like morphine, oxycodone, fentanyl, and Dilaudid (hydromorphone) break down into metabolites that are 'hyperalgesic', that is, molecules that can actually cause pain when they accumulate under conditions of chronic administration.

This might explain the experience of switching to more and more potent opioids which in turn produce more and more hyperalgesic molecules, and so a vicious cycle develops.

Methadone is different. It breaks down to methadone which is not a hyperalgesic substance.

The next part is non-intuitive: the higher the dose of the chronically taken opioid, the more relatively potent the methadone is when you rotate to it.

If you were to calculate the equianalgesic dose of methadone using the usual conversion tables, you will massively overdose the patient. Therefore, in an opioid rotation to methadone you calculate the equianalgesic dose and divide by three, usually, or at least by two.

Methadone is different. It breaks down to methadone which is not a hyperalgesic substance.

The next part is non-intuitive: the higher the dose of the chronically taken opioid, the more relatively potent the methadone is when you rotate to it.

If you were to calculate the equianalgesic dose of methadone using the usual conversion tables, you will massively overdose the patient. Therefore, in an opioid rotation to methadone you calculate the equianalgesic dose and divide by three, usually, or at least by two.

It goes on....
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Avatar universal
nope...nothing there but info on rebound headaches...i cant find 1 thing in reference to this...now i wonder if i have been talking out of my a** on this matter...i have read information on this forum about rebound pain, but not 1 thing to validate it....just more BS i guess... frustrating!
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Avatar universal
ok...i'll try again...when i did this before i only got rebound pain in reference to rebound headaches
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Avatar universal
try googling opiate use AND rebound pain.  I found many articles there that might be helpful to you - too many to list.
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Avatar universal
nope...sorry thats not what i was looking for...i am already on suboxone...i need information on" rebound pain from opiate use..."

but thanks for the new link to more information on sub for me...LOL!
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Avatar universal
thanks hun...i am worried about her...she has gone from 50 mgs of methadone to 100 or 120mgs  of methadone in less than 4 months...that is a big jump in a short amount of time...i will check it out...
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233181 tn?1235183152
Try pcssmentor.org There is a lot of info on there from sub to methadone to pain management, I hope you find something that helps her!-------------------Noah
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