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Addiction: Substance Abuse Community
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methadone metabolites

I am on methadone for narcotic addiction. My metabolites have came back very high in my urine analysis for the last couple months.  I am not taking any extra from what i am prescribed. What could be causing this?
1 Responses
4113881 tn?1415853876
Its your metabolism. You must have a slow metabolism.

Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs. Methadone has a typical elimination half-life of 15 to 60 hours with a mean of around 22. However, metabolism rates vary greatly between individuals, up to a factor of 100, ranging from as few as 4 hours to as many as 130 hours, or even 190 hours.  A longer half-life frequently allows for administration only once a day in Opioid detoxification and maintenance programs. Patients who metabolize methadone rapidly, on the other hand, may require twice daily dosing to obtain sufficient symptom alleviation while avoiding excessive peaks and troughs in their blood concentrations and associated effects. This can also allow lower total doses in some such patients. The analgesic activity is shorter than the pharmacological half-life; dosing for pain control usually requires multiple doses per day.
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495284 tn?1333897642
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