opioid receptors

[JLogan]

Hello team! I'm preparing for my big quitting day, October 1! I know some of you folks will question why I set a date, but I have learned from past experieinces that you have to plan for this challenge. My questions is, can anyone tell me what it means when something has "moderate in vitro affinity for opioid receptors"??

I want to try Requip for the terrible RLS I get during wihdrawals. My doc is helping me out by prescribing clonidine and trazadone to sleep, but I was thinking about adding requip. The RLS is my worst withdrawal symptom. And then I read a blurb about requip that said it "has moderate in vitro affinity for opioid receptors"

Can anyone tell me what that means?

Is it saying your brain thinks it is geting more vikes or percs?

Thank you as always! Stay strong!

Scotty in Phoenix

[worried878]

people have RLS/restless leg syndrome/even is they never had a drug problem///for opiod users get the "twitches" due to sudden dopamine/endorphin withdrawal//similar to parkinsons if u know someone with that affliction...the brain needs time to heal when u abruptly remove endorphins/the brain needs time to catch up/heal/initially u will feel the side effects of dopamine depletion///twitches/RLS/the brain will heal/time heals/stats say those who exercise regularly r less likely to have RLS/and the best cure for RLS is exercise...taking a drug to replace the dopamine is not always the best chopice.ur brain needs to kickl in aand do this on its own..some r dopamine defieicient from the get go///a dr's advice on these type of supps are best/wellbutrin is often an addicts replacement...but u gotta try what the drs rx to know...they will often start with an ssri/like lexapro/if that is not ur area of deficiency it will not help

Wellbutrin was originally used as an AD for an inpatient asylum...was noticed many quit smoking/possibly due to the relief of depression,,,it was then marketed as ZYBAN/a quit smoking drug...but in reality it is a dopamine enhancer..and can often be an addict's defiency...but no way to tell for sure...ssri's r the most commonly prescribed as they have the least side effects..if u r not seratonin deficient..an ssri doesnt really helps/cos it is not ur problem,...5htp is an amino that helps with seratonin....when i stopped hydros...and cracked down on th thomas recipe in the doses prescribed..i found tyrosine helped me the most//which is linked to dopamine/which is linked to wellbutrin///so i knew then my defieincy/the AD that would help me...had taken SSRI's before with no luck///if u do not take the right AD..then u r not helping urself

[JLogan]

Hey Twolve! My problem actually started with Ultram (tramadol). I was on it for a sports injury and my genius doc told me it wasn't addicting! I ended up loving the way it made me feel. I could concentrate a lot better and I was always happy so, of course I started upping the dose. When I was taking 9 at a time (and actually had a seizure!) I knew it was time to quit. This was last February. I survived 23 days of utter hell and felt free and clear after about a month. I beat it, I thought. Life was beautiful again! lol I truly felt great.

About two months later, my soccer team won a big tournament and I wanted to celebrate so I found one of my old stases and BAM I was once again a full-blown (instead of a recovering) addict. I didn't think I could survive another 23-day hell sentence so I made my second biggest mistake and tried Suboxone. Terrible medicine. I tried to cut down after about a month of using it and the WDs were 10 times worse than they were with the Ultrams. This time I have really done my homework. I know I can't escape without any withdrawal pain, but if the clonidine and trazadone can at least take a little bit of the edge off the WDs, I believe I will make, and make it for good this time, God willing. Tell me more about your ordeal...

[twolve]

I can't answer your question but I just wanted to congratulate you on truly wanting to quit. I am in Phoenix as well so we have that connection. I was doing oxys but I just recently changed to vicodin to taper off a little bit that my wds might be a little easier. I was able to quit last summer for four months so I know the drill, and it sounds like you do as well. What is it that you are quitting?