Therapy for high Ige levels?

[Lynx1113]

I am 38 years old and have battle allergies my life but began get huge hives a few years ago. After many allergy tests and rounds of prednizone, it was my allergy doctor who realized that I probable had high Ige levels....and blood work proved him right. I began my first series of Xolair with very high hopes. It worked great...but I rebound higher after each series. Normal levels are under 150...I started off with just slightly higher at 183. This was a couple years ago. I finished up my 4th series of shots (each series being 1 shot a month for 6 months) and my last blood work came back at 471...three times the normal high. This may not sound like high levels compared to some but I have learned that every body has a different tolerance. I am now getting the large hives again and looks like another round of Xolair is in my future.....once I can get my new insurance to pay for it. It IS expensive. It costs me $4000 a month and I have to go to the hospital to get the injection. I also have all the rare side effects to the medication.....severe ear pain, insomnia, exhaustion, irritability.....I never react the same each time. Xolair does work for me...no allergy medication or inhalers are needed while on the injection (which is great since I am allergic to Zyrtec....it gives me sever depression so I am afraid to take anything) and it has 'cured' me of COPD. If any knows of another therapy for high Ige levels...please share.

[bobosgirl1962]

I suffer from severe allergy induced sinusitis/ asthma.  I also get hives that make me want to rip my skin off. Here in the past year, I have been hospitalized more frequently.  September 2014. I spent 4 days in the hospital.   And then in February-March, I was hospitalized for 6 days. Each time receiving solumedrol and antibiotics.  Then going home on prednisone and antibiotics. Here at the midle of march, I once again am getting sick . I just started xolair injectons 4 days ago. And yet another dose of prednisone.  
I am misserable. My sinuses are a wreck. My asthma and allergies are out of control. The breathing treatments do not seem to be helping much.
I am looking to schedule sinus Surgery here in the near future. Depending if I can stay well enough to get clearance to go under anesthesia for the two hour procedure. I sure hope something changes soon. I am afraid that I will be returning to the hospital for treatment once again, before surgery can be preformed.  I am so misserable I don't know what to do anymore.

[Paderla Anitha, DNB]

Hello and hope you are doing well.

Basically the WBC or White blood cells serve to help the body to fight infections. Antibodies are produced to do this function. These antibodies are produced by a kind of WBC called plasma cells. These antibodies are proteins in structure. There are different types of antibodies called ImmunoglobulinsIg; IgA ,IgG, IgD, IgEand IgM, depending on their functioning capacity.

Increased IgG levels are generally indicative of an infection. However, Xolair inhibits the binding of IgE to the high-affinity IgE receptor on the surface of mast cells and basophils. This prevents asthmatic attacks.

Hope this helped and do keep us posted.