I've done a lot of research in the past week or so about Zoloft and the affects of alcohol. Since Zoloft is used to treat manic depression, I havn't found any answers. Usually doctors advise not to drink while taking this specific medication because it will cause advers affects therefore increasing your depression and you migth have random, harsh mood swings. All the asnwers pertain to depression. Since i am not taking this medication for depression, would i experience the same thing if i had a few drinks? i know that drinking while taking medication is not smart, but i am on the lowest dosage and dont plan on drinking daily.