If you're an anxiety sufferer, getting the jitters from the SNRI class of drugs is very common and is one reason many psychiatrists don't use them for that, including mine. Both Cymbalta and Effexor target both serotonin and norepinephrine breakdown, and the latter is a brain stimulant. Wellbutrin, which isn't an SNRI, also does that and can have the same problem. It's possible this will pass over time, and some with anxiety do pretty well on Effexor, though probably less so on Cymbalta, but most of them have as their main problem depression and anxiety as a lesser problem caused by depression, and stimulating the brain does help some depression sufferers. But if you are mainly an anxiety sufferer, you would usually be put on either the tricyclic class or ssri class of antidepressants, which isn't to say they will always work better or never cause agitation, as sometimes they do. In fact, Prozac often does. So you never really can tell for sure, it's trial and error, but for most people, stimulants don't go well alongside anxiety. And my own opinion after going down this road for way too long is, if a drug doesn't work for what you want it to work for, adding to it will just have you on a bunch of meds. You really want the main med to work well for you and be tolerated well before you consider adding another to it if you need something more. Peace.