I have taken Propanolol and Effexor for a couple of years with no issues. I don't take the Propanolol for anxiety but for a tremor in my hand. Propanolol is used as an anxiety medication, cluster headaches, high BP and tremors like mine. I have taken it with just about every antidepressant out there with no issues. At one time I also took a BP medication with it due to high BP and with no problems. Although with lifestyle changes I was able to get off of the BP medication. Pharamcists will not fill a presciption that will interact with the other, they will call your doctor. You can call your pharmacist and ask him about the two medications, they are most knowlegeable when it comes to drug interactions. Always take your meds as prescribed. Take care.