I hope Nursegirl answers, but she hasn't posted on here in a very long time. I don't know that she looks at the site anymore. The last time I sent her a PM she didn't answer. It seems that when she went back on Zoloft, she got a lot better and stopped posting, or so it seems. However, I can tell you that she won't be able to answer this question, as your experience won't be the same as that for someone else. We react to meds differently, we metabolize them differently. You are also taking so many drugs that it might be the combination of so many that slow metabolism that are the problem. Vistaril is an antihistamine that has an unwanted side effect of making people very sedated, as many allergy meds do. By marketing it as a sleep remedy they're making lemonade out of lemons, so to speak, but you're now on four meds that can cause weight gain because they target neurotransmitters either on purpose or accidentally that can cause metabolism to slow down. When this happens, it usually doesn't ever stop, because the drug keeps slowing your metabolism as long as it works. So you're likely to keep gaining weight, though there's no way to guarantee this. Since you're only taking this for "breakthrough anxiety," which is just another way of saying your drugs aren't completely getting rid of your anxiety, which is because drugs can't do this for most people, I'd suggest you learn to relax some other way, such as by learning meditation or increasing your exercise or doing something you can learn in therapy with someone who specializes in anxiety treatment that might hit the right button for you. At bottom, those of us who suffer chronic anxiety don't have a problem drugs can fix, what we need is to change the way we think. This doesn't usually work that well, but when it does, you're cured.