I'm wondering why your doctor would choose that drug at all to be honest (the buspirone). Have you tried any other anxiety medications? Is this because others haven't worked? Do you have narcolepsy? What I've read is that the Provigil is more likely to cause the buspar not to work verses the other way around. But the best source of information is a pharmacist who fills your prescriptions or the prescribing doctor who you should feel free to ask as many questions of as you need to feel confident. REmember, medication is just a small part of what doctors do--- they take not all that much pharmacology during med school and the rest is what they read/hear/experience. A pharmacist specializes in this information so that would be my next stop for info! good luck
What did your psych doc say about these issues you are concerned about?
My understanding is that, theoretically, Buspar works by targeting serotonin. But before you do this, if you have any concerns, research the research on Buspar -- it very seldom work. It didn't work in clinical trials. It keeps being tried for different things, trying to find a market. Right now it's only wide usage is when an ssri isn't working well enough to augment it. Now, a lot of people take it, and obviously many like it, but this is a very short half life drug that is more like a benzo than an antidepressant. I really doubt it will counteract your other drug, because it just doesn't work that well, but again, if you have any doubts, do your homework and decide if it's really worth it. Nobody on here is a scientist. Your pharmacist isn't a scientist but might know of drug interactions between these two. Your psychiatrist isn't a scientist, but should have experience using various drugs together. My own experience, long and sorry, is that most doctors including psychiatrists are really pretty clueless about the drugs they prescribe and how they actually work. This is made worse by the fact that many of the drugs we take have unknown reasons for why they work, if they work, and most don't beat placebo by all that much in clinical trials (I'm not sure Buspar has ever even beaten placebo). My take is, if you get any scientific inkling that the drug you need works and Buspar might conflict with it, well, you probably weren't going to benefit much from it anyway, though you might be one of the few who do. The drugs that do work for anxiety, however, are generally sedating, but some antidepressants are very stimulating and if your anxiety is a byproduct of depression, and it very often is, they might help both problems. Two example are the snri category and wellbutrin, but if anxiety is your main problem, these can be too stimulating for many people. Good luck in your search.
I read the entire thread and then more, trying to make sense of things.
We all know how inadequate & dysfunctional the medical system is and that's part of the reason we gather here.
All the technical mumbo jumbo is TOTALLY useless, when nobody can answer with any degree of certainty how these drugs work (or don't) on jwright84
Please read on:
This is a particularly complex case and unfortunately many important details in this post were left out!
No, jwright, I cannot see how you only had success with medications, when from what I read, you are forever dropping, adding, switching, adjusting medications, which BTW, at present, have Twelve Drug Interactions between them, out of which 5 are Major Interactions!!! (you are at an increased risk of Serotonin Syndrome, but your prescribing doctor and your pharmacist should know this, right?)
In addition you are on 5 Central Nervous System (CNS) Drugs, when the recommended maximum is only 3
(taken concurrently). And also on 2 Anti-depressants, when only one at a time is the recommendation.
Perhaps, your doctors have a very good therapeutic intention for prescribing all these meds, understanding the possible consequences and implications, after doing a thorough risk-benefit analysis. But I doubt that.
Here's my honest opinion, which I'm offering, in order to help you get on the path to better health and recovery.
I don't think your body needs another drug to help you stay awake during the day.
As much as you want to fix some things in your life, you need to go deeper, beyond just fixing issues that may have to do with drug side-effects, drug interactions or symptoms of unresolved imbalances/conditions.
It sounds that you have a sleep debt and a major factor
is likely the sleep apnea.
Sleep apnea brings its own set of anxiety,stress and other symptoms.
Your 2 diagnoses are distinct and treated separately, yet treatment must be in concert, as well.
Being obese is a factor in both anxiety and apnea.
Also obesity causes Vitamin D "functional" deficiency, -even if your vitamin D levels test normal- in the form of vitamin D resistance (VDR). Much higher levels of D are necessary to make up for VDR.
Chronic pain is another source of stress.
There could be a strong connection between obesity,
Vitamin D deficiency and your Spinal abnormalities.
A functional deficiency of calcium is highly suspected, where calcium is leaching out of your bones faster than
deposited, as calcium intake is mostly un-metabolized.
To make matters worse, a magnesium deficiency is also highly probable, which is vital in optimizing calcium deposits in the bones and joints, dealing with stress and anxiety, increased energy etc.
Other things to consider, which might be going against you are:
*Leptin-Resistance, High Cortisol (or Low Cortisol, depending on how long your adrenals have been stressed), hypothyroidism possibly type 2 (thyroid-resistance), lack of a neurotransmitter assessment.
* Disregard the ones which might have been already PROPERLY addressed and/or ruled out.
There's very little hope that your meds, will do any more than just maintain you, which will continue being an
ongoing battle, unless the underlying issues are properly addressed.
The natural approach you mentioned, needs to be very comprehensive and under the guidance of an experienced Practitioner.
Getting some supplements, ACV and other suggestions
from internet sources or acquaintances etc, does not constitute a professionally designed natural treatment plan.
If I were you I would also look into genetic analysis,
since there seems there might a genetic component in some of your conditions. Some genetic mutations can
be influenced by specific targeted nutraceuticals and
many can be totally reversed (in combination with
eliminating other environmental/lifestyle contributing factors)
I just lost a friend of mine in September to cancer, who
for many years had been on at least 15 different meds, also with a great number interactions and dublications, from sleep medications to pain killers and statins, diuretics, SSRIs, PPIs, ACE inhibitors Tylenol 3 ...
He never really trusted his doctors; I knew that, even if he didn't openly expressed it.
But he was afraid to initiate significant change, just in case!
You are still quite young. and you now have a daughter.
If she's not enough of a motivation factor for you to turn things around drastically,.I don't know what is.
Well, I'm going to be brief and to the point w/o much detail and I would encourage you to do your own online searching for verification and to get further details or instructions.
-- Your D3 intake should be accompanied by adequate K2 and Magnesium(transdermal mg oil daily), as I think your mg usage is very high and you won't be able to handle high amounts of oral mg, which BTW has very poor absorption.
You're probably metabolizing calcium that ends up in the wrong places!
Calcification is a very bad thing!!!
-- Mg (conventional serum) testing is useless as it shows almost always normal at 1-1.5% and tightly controlled.
Get an RBC mg test instead.
-- Methylocobalmin B12 is great. Add also Methylfolate and avoid any unmethylated forms of these 2, b.cause they plug the respective receptors
Alternatively try SAMe supplements.
Toss your multi-vitamins if they contain folate/folic acid and cyanocobalamin.
Watch for vitamin- fortified foods since the vitamin quality is low and the form wrong. Simply avoid them.
Your methylation will improve drastically if you follow the above. This is HUGE!!! Google it! It has to do with a gazillion biochemical reactions in the body and almost nothing goes right when methylation is impaired!
Note: Contra-indication if COMPT genetic mutation homozygous or heterozygous.
--Lansoprazole could be a source of many issues.
Are you taking it for GERD?
Low stomach acid could result in low absorption of vitamins, nutrients and minerals and lead to numerous deficiencies, many of which are not diagnosed due to
flawed testing or simply not tested!
The majority of GERD sufferers have low stomach acid!!!
Follow the $$$$. This class of drugs is a huge profit center for Pharmaceuticals!
--Thyroid tests TSH and T4 are simply flawed.
They only indicate serum levlels
You need Free T3, Free T4 AND Reverse T3 to test for Thyroid function in your cells!!!
Note: Caution in treating low thyroid function if your Cortisol levels are high! You need a stress profile saliva test 4 x cortisol and DHEA (see BioHealth Labs site for details.)
-- Most Doctors don't bother to suggest detox, but you should look into it, starting with colon cleansing.
--Finally genetic testing. I have dealt with 23andme, online and I can decipher most of their reports (they come w/o analysis and there also a few other websites where you can get your results analysed for very little.
But I think 23andme genetic testing is no longer available within the US.
(Fearing some people might do their own diagnosis and treatments according to their genetic profile and eventually screwing up, or simply seeing these types of tests as a threat to "their" business?) Hmm
I live in Canada, but my test was done in Holland.
This can reveal invaluable information, specially in light of all your imbalances and your medications.
One great benefit would be the ability to target your treatments better and to bypass genetic mutations where possible.
Your lost your keys in your house.
"Why do you look for them across the street under the street light? "
---"Because there's a total power outage at my house."
The question about magnesium interfering with anti-depressants kinda reminded me of the above,lol
Here's some articles' titles (just search under the titles)
pertinent to magnesium which may help answer your question:
1. Magnesium deficiency in plants: An urgent problem.
2. Magnesium deficiency and stress: Issues of their relationship, diagnostic tests, and approaches to therapy.
3..Interactions between magnesium and psychotropic drugs.
Magnesium, being already low, due to stress, anxiety and soil depletion should be supplemented rather aggressively when on certain medications including anti-depressants. This will add significant therapeutic value to your current treatment.
The real question is: Will oral Mg (even in the best form)
be able to make up for the 3-legged deficiency and reach optimum therapeutic levels?
Personally if I were you (jwright) I would also do the transdermal, as an adjunct.
And BTW I used the Interaction Checker and besides your 12 major and minor interactions between your drugs, the only other ones worth mentioning were with alcohol, caffeine intake and also it made a note of increased BP with SSRIs. No mention at all of Mg.
Of course, judging from all the " junk " medical papers,
articles and studies I have personally come across, I wouldn't be surprised, should Mg be found guilty of causing some dangerous consequences.