I have realy hard time lately, you probobly know what I mean... I have soft bipolar, bipolar II with no mania. Week and a half ago after takin 250 of Depakote for about 2 months and taking 500 for about 1 month (blood work was done) my doctor decided upper me up to 750 for a week then take 1000mg. At the same day I went up to 750 I have decreased my Xanax XR cutting down frm 1.5mg to 1mg. I was taking the Xanax for almost two years. First two days on higher depakote and less xanax was fine, third and fourth i felt depressed, anxious, my head was clouded, couldn't concentrate, think, weird sensation on the face,diarrhea, weekness, sleepy, I was a wreck. Then next two days was much better, but then it started again but the symptoms are less sever, but iI still cannot concentrate and have cloudy head and derealization, face sensation, blurry vision, diarrhea anxiety that I will never be better. Two days ago I upped my Depakote to 1000mg. Yesterday, I had bad depression episode for about 3 hours in the afternoon, I was crying. I see that Depakote controlls my cycling, I am not going up and down that much. I really want it to work and live normal life :-(. My question is, are the symptoms I experience side effects of Depakote or withdrawal from Xanax???? Please help me!!!!! I am sttill taking .5 Xanax Xr in the mn and .5 in the evening so it is still there, I've just reduced the dosage!!! I also take small dosage of 600mg lithium, 25mg of lamictal and 2.5mg o Lexapro a day. Most of them my pdoc wants to get rid off. Thanks!!