Ok, since I started having bad anxiety three months ago and I started taking Zoloft a month ago I have lost 10 pounds. Now, I have stopped lifting weights 3 months ago and stopped taking supplements. That could explain 4 pounds maybe.... But, does Zoloft make you loose weight...I mean I have been eating like crap to put on weight. Twinkies, Zebra Cakes, and other junk food... Not putting on weight. Does Zoloft cause weight loss?