Anxiety Community
23k Members
Avatar universal


Hello. I've recently been changed from Paroxetine to Zoloft as am looking to try for a baby and this is supposed to be 'safer'. My doctor has changed me over gradually.  I took Paroxetine 20mg for 2 weeks plus Sertraline/Zoloft 50mg, then went to Paroxetine 10mg and Sertraline/Zoloft 50mg and 2 days ago I've stopped Paroxetine altogether and am now just on Zoloft 50mg...I'm off work today as I'm so depressed. All I want to do is cry and lay in bed.

How long does it take for Zoloft to kick in? I have been on it for 4 weeks now. ..shouldn't I be feeling better by now?

Am so depressed as I really want to try for a baby and I know I cant be on Paroxetine so scared ill be like this throughout my entire pregnancy when I want to be happy and enjoy this time.  

In an ideal world I don't want to be on any meds but I have such bad depression and anxiety that its not an option for me...feeling annoyed that the Paroxetine worked well and now I can't be on it anymore!!!

10 Responses
Avatar universal
I think you really need to give it more time, as you were cross tapering and need to wait until the paxil is out of your system. ZOloft is a great drug and you need to just give it time to work. I was on it when I had my baby and loved the drug, just give it time!!!
Avatar universal
Thank you for your reply - it means a lot :-). I will do. I'm hoping it will kick in sooner...may need to increase my dose. Did you have any problems taking it in pregnancy? I'm so scared of harming baby xx
Avatar universal
For me, Zoloft seems to work fairly well. I know with me, any time I adjust or switch meds (under the direction of my doctor), I do notice some increased anxiety.   Are you in counseling right now?  I know for me, the best way to deal with the anxiety was a combination of the therapy and medication....keep us posted!
Avatar universal
Hello. No I'm not having counselling. I've been on wait list gor nhs for over a year and can't afford to go privately. Tjis should be such a happy time of my life...am so sick of things never going smoothly for me...when will it be turn?! Sorry to rant!! Thanks for your reply xx
Avatar universal
It's not that simple.  Paxil is known to be stronger in its affinity for serotonin receptors than Zoloft, and is very hard to stop taking if you've been on it for awhile.  There's absolutely no evidence that starting a new drug before you've withdrawn successfully from the old one works, though I'm sure some people do it well.  Your taper off Paxil has been very fast.  I would have recommended stopping the Paxil completely before switching, and it appears you're suffering some paxil withdrawal symptoms now.  I also don't know that Zoloft is any safer for someone having a child, although given it isn't as strong in action it might be a tad safer.  Also, as to the above post about Paxil being out of your system, I keep reading that on here, but Paxil and Zoloft both leave the body very quickly, within hours.  It's the brain trying to adapt that's the problem, not the drug being in the system.  I hope this all works out for you.
Avatar universal
By the way, I'm not trying to be pessimistic here, just want you to be vigilant and keep your psychiatrist on his or her toes.  Peace.
Have an Answer?
Top Anxiety Answerers
Avatar universal
Arlington, VA
370181 tn?1428180348
Arlington, WA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
Find out what can trigger a panic attack – and what to do if you have one.
A guide to 10 common phobias.
Take control of tension today.
These simple pick-me-ups squash stress.
Don’t let the winter chill send your smile into deep hibernation. Try these 10 mood-boosting tips to get your happy back
Want to wake up rested and refreshed?