I have taken xanax occasionally for many years, only in case of emergency panic situations or when flying or other high stress situations. Usually a .25 works to ease things out, sometimes I have to go to .5, never any more. this has always worked for me, it is my security blanket, I don't go anywhere without taking my pill bottle....but I only take them between 1-2/wk to 1/a mo. and if I'm doing really well, even less. Recently a doc switched me to klonopin 1mg as needed, but I had many xanax left over in my old script, and since I was comfortable with the effects, I stuck with the xanax. I tried the klonopin as a preventative before a stressful situation a few times and I didn't have any probs with symptoms, so I figured that worked too. Then one day before an event I took the kpin and it had no effect. I had an attack in the middle of an event...it was like I hadn't taken anything. I know that it actually works best taken regularly, so I started to take the klonopin daily in .5 doses twice as day, but then I backed off it, as I kind of got scared of taking a daily med, even though my anxiety has been high lately. So I took the .5 2x a day for 3-4 days, then cut it in half for a few, then 1/2 that (which may have been an uneccessary taper given the short duration, I don't know) I guess i don't really know if it would have worked as a daily, since I backed out...I do know that10 years ago, I took a daily benzo(tranxene) and it worked beautifully. But a doc took me off of that and onto effexor, which I discontinued 2 years ago. But anyway, after no kpin for 5 days, i had a panic attack at work and took .25 xanax...I was still losing my mind 45 min later, so I took another. Again, it was like I hadn't taken anything at all.....no effect! How can this be?? If benzos don't work anymore, my life will be severely limited:( Has anyone else ever had this happen? How can the effect change so drastically...sometimes a 1 mg kpin has made me so sleepy, It practically knocked me out..Any ideas?? I appreciate any thoughts you good people may have. thanks!