The half-life of methotrexate is about 12 hours. It should leave the system within 1-2 days.
The decision of whether to drink alcohol after methotrexate should be made in conjunction with your personal physician.
Followup with your personal physician is essential.
This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.
Kevin, M.D.
http://www.straightfromthedoc.com