A CCP test may be ordered along with or following a Rheumatoid factor (RF) test to help diagnose Rheumatoid arthritis (RA). CCP may also be ordered to help evaluate the likely development of RA in patients with undifferentiated arthritis – those whose symptoms suggest but do not yet meet the ACR criteria for RA. According to American College of Rheumatology, approximately 95% of patients with a positive CCP will develop RA in the future.
When is it ordered?
CCP is primarily ordered along with an RF test when a patient has previously undiagnosed inflammatory arthritis or has been diagnosed with undifferentiated arthritis. It may be ordered as a follow-up test to a negative RF test when clinical signs, such as symmetrical joint pain and inflammation, lead the doctor to suspect RA.
What does the test result mean?
As a rule, test results outside the context of clinical signs and symptoms cannot be judged. Nonetheless, when patients are positive for both CCP and RF, it is very likely that they have RA and it is likely that they may develop a more severe form of the disease. When patients are positive for CCP but not RF and clinical signs suggest RA, then it is likely that they have early RA or that they will develop RA in the future.
When patients are negative for CCP but have a positive RF, then the clinical signs and symptoms are more vital in determining whether they have RA or some other inflammatory condition. When patients are negative for both CCP and RF, then it is less likely that they have RA. It must be emphasized, however, that RA is a clinical diagnosis and may be made in the absence of positive autoantibodies.
Is there anything else I should know?
The CCP test is promising and becoming more widely used; however, its ultimate clinical usefulness and the ways in which it will be used have yet to be fully determined.
Copyright 1994-2018MedHelp.All rights reserved. MedHelp is a division of Vitals Consumer Services, LLC.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.