My grandmother will be 89 shortly and has been as healthy as they come for all of those years (she is usually so vibrant and full of energy that strangers estimate her to be 15/20 years younger) In the past year she began to experience shortness of breath, which eventually was diagnosed as a weakening of one side of the heart muscle and she was put on oxygen therapy at night (with occasional uses during the day if she feels really out of sorts.) She then developed a sharp pain in her lower back. She was prescribed a combination of Lyrica and Cymbalta for her back. (Understand that if she goes to the doctor's appt. w/out my mother - never again- we don't get a complete explanation for why something is being prescribed) She has never had a need to take ANY medication with regularity aside from something such as Fosamax. Since beginning to take these medications, she has become confused, drowsy, forgetful and is on occassion beginning to not be able to remember her own address or phone number. Up until recently, she never slept past 6:30 and upon getting up would get herself dressed to a "T" and "put her face on". And she was consistently in bed at 9 p.m. after washing up, to watch the news.) In the past week, my mother dropped by at noon and Gramma had not been out to pick up her paper (mom usually drops by each day around 2 or 2:30), was still in her pajamas and was cooking something on the stove. It was obvious that Gramma had not been up long, she was shaky from not eating, and very out of sorts. 2 days later she was to meet my parents at their house at a certain time (they live within a 5 min. drive of each other). She showed up an hour late and was as hot as fire (Temps outside were probably in the low to mid 90s). Apparently, she'd spent that time sitting on a neighbor's patio 6 doors down waiting for my parents to come home. She'd tried her key in the lock and couldn't figure out why it wouldn't work (these houses and their patios look NOTHING alike). There is no telling how long she would have sat there waiting on the patio if the owner's of the home hadn't turned up. There have been several other incidents recently that gave us pause besides these. Very scary incidents to us (i.e. she thinks my Mom has spent the night at her home so makes extra coffee for her, but doesn't want to go wake her up. Mom doesn't live there or stay the night EVER.) She is not herself and this type of confusion etc did not begin to turn up until she began taking these drugs. I am firmly convinced that the meds are the problem vs. dementia or Alzheimer's as the symptoms came on so suddenly. I apologize for the long post, but wanted to explain as fully as I could my concerns and FEARS. We would appreaciate any and all thoughts and comments on Lyrica and/or Cymbalta in the elderly (oh, how she would cringe to be referred to as elderly..) especially examples good or bad and also any alternatives to that type of drug therapy. My Mom has scheduled an "emergency" doctor's appt. for her this coming Thursday (6/19.) It would be very empowering to be able to go in there with some suggested alternatives to what she has now, as we cannot have her quality of life diminish so rapidly- we miss her true self too much and depend on her wise counsel.