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dicoflenac gel

Topical pain drug can kill your liver!
The FDA just announced that dicoflenac gel (brand name Voltaren Gel)  often prescribed for arthritis pain  is linked to severe liver damage and it can happen within the first month of use
According to the FDA, this topical gel has been reported to cause liver necrosis (death of liver cells), jaundice, and liver failure some cases of which have required liver transplant and some that have been fatal!

Despite these horrible side effects, dicoflenac gel remains on the market.
2 Responses
469901 tn?1276563623
Here is the link to the FDA report dated 12/4/09

http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm193047.htm
Avatar universal
Link doesn't work anymore. Anyway, the resorption of topical Diclofenac is minimal!

https://www.pharmazeutische-zeitung.de/ausgabe-5152532009/fda-warnt-vor-leberschaeden/

Translation via DeepL.com

all-clear from the manufacturer
Voltaren manufacturer Novartis points out that in more than 20 years of application experience in local pain therapy, liver damage or severe hepatic reactions have never been reported. The FDA's goal of harmonizing technical information relates to high-dose long-term systemic therapy. As there is only little experience with topical Diclofenac preparations in the USA, the approval authority evaluates the topical preparations just as the systemic ones. According to Novartis, no liver damage is expected when Voltaren Pain Gel is used as directed. Only 6% of diclofenac would be systemically absorbed by percutaneous use. /

Translated with www.DeepL.com/Translator (free version)
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