I have had about 3 different series of injections in my knee which has severe osteoarthritis. Two series were Synvisc; one was Suparts. None of these has provided significant relief of pain or increased mobility. I have always had these injections done in the doctor's office. I have been reading on the internet that about 25% of these injections go into the fatty tissue and do not give maximum relief. Therefore, giving the injections under fluroscopic guidance puts the medication into an optimum location in the knee joint and is much more successful. I would like to know opinions on this, success rates using this type procedure, and any other additional information since I am considering trying this route in a few months. Many thanks for any information provided!