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Prozac and Bladder Pain/UTI

I have taken Prozac twice before (each for a period of six months). I just recently started Prozac a third time. Starting dose is 20mg taken daily.

My first time on Prozac, I suffered multiple UTIs. All uncomplicated infections, but painful nonetheless. My second time on Prozac, I got the worst UTI of my life one week into treatment and switched to Buspar.

I've had no UTIs while off Prozac or on other medications.

I started taking Prozac again six days ago. It started on day two with bladder pressure after urinating. Now I have burning after urinating and severe bladder pressure and cramps. All of which I believe are the start of yet another UTI.

Is it possible that my Prozac prescription is causing these painful bladder issues? I've taken a home UTI test, which was negative. Is it possible the Prozac is simply causing bladder pain as a start up side effect that will go away without turning into a full blown UTI?
1 Responses
5801192 tn?1389204087
Dear DaintySabrina:

You know your body the best.

If you experience a serious side effect, you, your doctor, and/or pharmacist may report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program by:
1. calling 1-800-332-1088, or
2. go online:http://www.fda.gov/Safety/MedWatch

Upon reviewing the manufacture drug label on fluoxetine (Prozac), there was reporting of adverse effect on "urinary frequency", but not on urinary tract infection, or UTI:
"Other adverse reactions in pediatric patients (children and adolescents) — Treatment-emergent adverse reactions were collected in 322 pediatric patients (180 fluoxetine-treated, 142 placebo-treated). The overall profile of adverse reactions was generally similar to that seen in adult studies, as shown in Tables 4 and 5. However, the following adverse reactions (excluding those which appear in the body or footnotes of Tables 4 and 5 and those for which the COSTART terms were uninformative or misleading) were reported at an incidence of at least 2% for fluoxetine and greater than placebo: thirst, hyperkinesia, agitation, personality disorder, epistaxis, urinary frequency, and menorrhagia."


It is not conclusive if taking fluoxetine (Prozac) cause you to have UTI, since it may also due to your depression. As you know, when we are under stress, our immune system is weaken and may be compromised.

It is a good idea to consult your psychiatrist, OBGYN, and primary care physician to see if there are any other underlying causes. Are you taking any other medications that may be immunosuppressive and lead you to have UTI?

I see you are also on melatonin. What are you taking it for? Melatonin is generally considered safe for most adults to take short term. However, it does have a lot of drug and disease interactions. For patients with depression, melatonin may worsen the depression symptoms.

From literature, it is interesting to see that SSRI or selective serotonin reuptake inhibitors, such as fluoxetine and paroxetine, have been used to treat interstitial cystitis, a common bladder condition characterized by bladder pain, nocturia, and urinary urgency and frequency. Not sure if this information helped or not, but it would be good to consult your OBGYN or primary care physician.

For more information, please go to:
1. Fluoxetine - Daily Med

2. Melatonin - Medline Plus

3. Depression - NIH
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