Patients with severe asthma are the ones most likely to develop airway remodeling. Asthma involves inflammation of the airways in response to specific triggers. Possibly dust mites trigger the inflammation, in your case. Inflammation causes permanent structual changes of the lungs. Airway remodeling is the term for these permanent structural changes of the lungs, Patients may notice increased mucus. There are also other changes that occur within the lungs that will lead to their reduced ability to move air into and out of them. Medications can help control the inflammation that eventually results in airway remodeling. Sometimes medications cannot.
I maintain my previous recommendations. You need a comprehensive examination.
I am still wheezing and having exhaustion/cognitive problems. I tried steroids but they didn't stop the wheezing but I think I need more prednisone to breathe.
Is my lung obstruction becoming fixed because of airway remodeling??
There is no simple answer I can provide for you. You certainly have troublesome symptoms that may or may not be related to allergy, asthma, and/or chronic pulmonary obstructive disease (COPD) This forum can never substitute for a proper examination. I can not see you, and don't know even the most basic information, such as your age, occupation, and smoking history. Even though your chest x-ray was reported "clear" you still could have COPD. Your health care provider who reviewed all the tests you have had may have determined that your present FEV1 may be the best that can be expected. Peak flow is not a "stand alone" number but it is encouraging your peak flow improved. Your physician may consider giving you a peak flow meter and an "asthma action plan."
Is your ESR 155 or is your IgE 155? If your IgE is 155, you would not be a candidate for Xolair. If your ESR is 155, then your health care provider, who knows you, may consider an autoimmune process or other medical condition associated with this ESR measurement.
You tested "positive" for dust mites. You may consider immunotherapy.
I still would urge you to undergo a sleep study. The pulmonologist who orders it may direct the technician administering it to apply CPAP if he believes it may be helpful for you.
I sense you are extremely concerned about your symptoms - Sometimes patients go to several different offices looking for a "cure it now" and a serious condition may be overlooked, as specialists tend to be focused. I hope you have a primary care provider who has reports from everyone who examined you to make an informed judgement over diagnostic and treatment decisions.
do I have allergic asthma based on these tests?
should I test for autoimmune diseases or get a lavage, bronchoscopy?
Hello Eliot,
It is very unhealthy for you to sleep with such a low oxygen concentration; very stressful on vital organs such as your heart and brain. Corrective action should be taken by you and your doctor to keep your oxygen level above 90% during sleep, whatever that may require, oxygen or a positive pressure breathing machine. The other thing to keep in mind is that when a person lives with an untreated sleep disturbance, that alone often makes it very difficult, if not impossible, to control one’s asthma.
You describe your FEV1 as “stuck at 72%). There is a wise range of normal values when it comes to “normal predicted values.” Your value could even be described as borderline low normal and, assuming that you are using proper technique, your peak flows are in the so-called “normal range.” I am surprised to hear that you would wheeze with exhalation at a time when your peak flow is greater than 400. That makes me wonder if the peak flow numbers are valid or if the wheeze with exhalation is really coming from your lungs; if maybe it is coming from your upper airways and the “breath stops” occur for some other reason.
The best advice I can give is that you arrange to see an asthma specialist, either an Allergist or a lung specialist (Pulmonologist), for a careful examination of your breathing to find out if there is more going on with your breathing than meets the eye.
Good luck
I took this ESR test for xolair and my IGE was about 155 and I have level 3 allergies to dust mites. it does increase risk of infections/cancer though
You could ask your doctor about Xolair, to see if you are a candidate for that treatment. You will have to take a blood test first.
As far as your "harmful and dangerous sleep" if you have not had a sleep study, ask your doctor about that; you may benefit from a therapy called CPAP