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144586 tn?1284669764

Prednisone, GERDS, throat infection

Some physicians provide asthma patients with emergency supplies of oral prednisone tablets, to be taken in accordance with a specific short-term protocol.

These high doses compromise the immune system and the patient becomes vulnerable to opportunist infections. This is a mixed-bag because without the prednisone the patient may die from lack of oxygen.

In any event, the esophagus is very vulnerable to infection when eroded by stomach acid oozing through the esophageal sphincter. This is common with GERDS and acid-reflux syndromes. Normally the esophagus and trachea are very resistant to infection If there is acid refluc, the situation changes. The acid destroys the barrier to bacterial infection, and together with the prednisone the patient becomes prone to a sore throat, and infection which may rapidly progress to the lung.

Thus, the drill is, when on high-dose oral predisone, avoid esophageal acid erosion. I don't know why this information is not widely known.

This is accomplished by:

(a) not eating within two hours of sleeping.
(b) avoiding foods that contain methylxanthines (chocolate), which relax the sphincter.
(c) avoid "floor eating/snacking". Always eat while sitting in an upright position.
(d) sleep with the head at a thirty degree angle or more.

If you have a diagnosis of GERDS, make a special effort to keep things under control while taking the prednisone.


(c) consider taking an antacid while taking the prednisone.
10 Responses
746512 tn?1388811180
Plus prednisone can cause or increase the amount you are refluxing.  

It normally didn't help my symptoms at all until the course was done because I have bad reflux.  I would use this medication only as a last resort with a history of GERD.
Avatar universal
I take nexium and zantac for my GERD.  treating GERD may help asthma and sleep apnea.  perhaps the acid causes inflammation.  it may also be better to avoid any spicy foods, allergic foods, nuts, milk, lemon, acidic foods

prednisone may cause brain damage long term to the hippocampus and the neurons there.  so getting steroidal injections or taking high doses seem questionable in some situations.
Avatar universal
I really need to know, how low do your FEV1, FEV1/FVC, peak flow meter scores have to be for there to be airway remodeling and risk of permanent scarring?
if your FEV1/FVC is above 100 are you safe or are there other measures or airway remodelling?
Avatar universal
it seems that even low doses of prendnisone can leave you open to herpes lip infections

hi!  an asthma sufferer told me spirulina and spinach and algae may help asthma
http://cat.inist.fr/?aModele=afficheN&cpsidt=13491008
she claimed she was able to stop inhalers
there was one dramatic story on an internet forum but safety?  also I ordered
amrita bindu an Indian mixture that was dramatic in on one study.
I also take boswellier extract and vitamin D, C

I think spirulina is available at vitamin shoppe, gnc

I have this wheezing on exhaling, might be vocal chords.  also when I take oxygen on bipap I seem
to feel much better and can think clearer.
it is a terrible, terrible suffering to have sleep apnea.
Avatar universal
my question too is if prednisone causes memory and brain damage to your neurons long term even at doses of 10mg/day
Avatar universal
My father-in law use to take 10mg every day for years for his asthma...I think there are other things to worry about  besides your memory...his didn't seem all that bad, but his bones got bad...he shrunk alot!  I think at one time he was maybe 5'5" or a little taller, by the time he died I don't even think he was 5', he was hunched over and he was very puffy looking.  But if he didn't take it, he couldn't breath, so no option.

You have to weight the options for long term use.  For short term use, I have to give it to my son (also asthmatic) usually when he gets sick with a cold...his asthma gets so bad, it's the only thing that works for him...I hate it, but again, no option.
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