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ANA Results - what do they mean?

Hi all,

I'm a 26year old female and for years I've had strange autoimmune, hematological issues including being diagnosed with cyclical neutropeania, which seems to have quietened down and my neutrophils although low are much more steady now. I have always had a positive ANA result, my latest was 1.640 nucleor pattern. The only reason I am now concerned about this is that my sister has been diagnosed with polymystosis which is horrendous. Years ago a particularly socially challenged doctor casually said to me that I would probably get lupus in 10 years or so. I put it in the back of my mind, but now its bothering me alot. Should I be concerned now about this result? I have no symptoms other than I get wrinkly fingertips and I have some burst blood vessels which my doctor says is Raynauds but again nobody really very makes me feel better. Any feedback would be wonderful, I would love to not worry about this all the time.
Best Answer
1530171 tn?1448129593
Stress is the #1 factor in initiation of chronic disease.
This pertains to the broad meaning of stress such as trauma -including physical and emotional-, injuries, infections,vaccinations, etc.
So this might explain the onset of your chronic issues.

Genetic predispositions without stress or other contributing factors are just that-predispositions. (I have met Dr. Bruce Lipton at a conference-"Biology of Belief" and "The Wisdom of your cells" and his work and research well establish it)
A strong immune system is probably protecting you presently.
It is your best line of defense. Pay particular attention to your digestive and GI health as 80% of your immunity lies within the gut.
One grossly overlooked key area to ensure good health is keeping the JNK  gene inactive-it "resides" in each and every cell of the body-.
Prolonged activation of this gene ALWAYS  leads to SERIOUS chronic disease.
There's a lot of buzz lately on the internet. One does not need to buy into any of the JNK programs,supplements and diets that are being promoted.
If interested to keep the JNK gene dormant or if you need more info, let me know, as I am using a very simple method to achieve this.

Meanwhile, keep doing whatever you have been doing to stay healthy!
Wishing you well!
Take care.
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1756321 tn?1547095325
Info from fpnotebook. I've added some more info in [ ] brackets :)

Nucleolar Pattern:


CREST syndrome [The limited cutaneous form of systemic scleroderma (lcSSc) is often referred to as CREST syndrome - Calcinosis, Raynaud's syndrome, Esophageal dysmotility, Sclerodactyly, Telangiectasia]

Further evaluation tests:
Scl-70 kD kinetochore (Anti-Topoisomerase I) [sensitivity for scleroderma: 22 - 40%]

PM-1 [one study found 67% was associated with a polymyositis-scleroderma overlap.  It occurred less frequently in polymyositis, dermatomyositis and scleroderma, and was not detected in other rheumatic diseases.]

Normal titer less than 1:20 dilution

Low Positive (1:160 or lower): Low significance

High Positive (1:320 or higher): Higher significance
Helpful - 0
1530171 tn?1448129593
Hey MissT85.
When your neutropenia is low cycling do you know what is the  ANC ?
Have you ruled out deficiencies (as Co-factors)?
What are you taking for this, and have you considered any immune system modulators? Have you had confirmation for Raynaud's-Have you had the extremeties examination under microscope or dermatoscope? Any hot and cold sensations or tingling?
Sorry about asking all these questions, but please post your answers along with anything else that you consider significant.
I will reply soon and promptly.
Take care
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Avatar universal
Hi Niko,

I'm not sure what ANC is but The neutrophil level was cycling from 0.2 through to 1.5 every three weeks. It is now around 1.5 - 1.9 most times and nothing else shows up out of the ordinary anymore. I have never had confirmation for Raynauds - the diagnosis consisted of the immunologist looking at my test results, then asking me questions about my hands and whether they change colour and burn - which they do. They also were really interested in these broken blood vessels on my lips which they called telangasia? although they didn't really say much about this. I haven't taken any immune modulators since my neutopenia stabilized but I was taking the Hg shots for about a month 4 years ago but nothing since. I don't know if it is important, but all my immune issues seemed to start after a really severe case of glandular fever 10 years ago which saw me bedridden for alot of the time and from which I never really felt the same after - always tired and always run down with recurrent tonsillitis. I also developed sinus tachycardia after this - which they said was likely genetic but I had this ablated with moderate success.
To be honest I feel for the past few years I am in good health and have no real complaints, I am quite active and eat well, but I do have a fear of what is going to happen in the future, especially because of my sister. Is it possible I could just continue in good health and that these results mean nothing?

Thanks for your help.
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Avatar universal
Hi Niko,

Thanks for your advice - I have always felt that stress brought out some symptoms but I usually have people dismiss it. I am interested what you have to say about the JNK gene, if you could send me more info I would really like to read it.


Helpful - 0
1530171 tn?1448129593
Hey Tara!
Please search Medhelp (not a general search) and type JNK.
You will get about 5-6 posts of mine regarding this gene.
Next post when I have a chance I'll post the exact procedure how to supplement.
Helpful - 0
1530171 tn?1448129593
Hey Tara!
Here's what I do:

What I take and also recommend to people- for controlling the JNK gene activation- is to supplement with Undenatured Whey Protein Isolate Powder. It must be certified Undenatured!
No heat, no blender can be used !
10-20 grams is one dose. Take 3 times daily -away from meals- just mix well with a spoon in your juice or in a smoothie (no blender!).
It has no taste and it's recommended to use unflavored.

There's a lot of marketing regarding the JNK diet, however:
  The JNK diet -to my opinion- is not necessary as the above supplementation with the undenatured whey  protein will produce probably  the same result: Increased Glutathione levels.
  Glutathione helps Inhibit GNK gene activation.
Let me know if you have any questions.
Take care,

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