ASMA - Anti-Smooth Muscle Antibody can be seen in infectious mononucleosis & other viral infections, Systemic Lupus Erythematosus (SLE), breast & ovarian carcinoma, and melanoma. It can also be seen in about 50% of cases of primary biliary cirrhosis, alcoholic related cirrhosis, and cases of biliary duct obstruction.
At a starting dilution of 1:20, there are many false positives for ASMA at this low titre level. ASMA is found positivity in 1.2% of "normal" people under age 40 and in 3.5% over 70 years of age.
Associations with elevated levels of ASMA antibodies:
Autoimmune (chronic active) hepatitis (AIH): 50 - 80% of cases, 70% at >1:1002; >1:160 is significant serologic evidence - suspicious for autoimmune hepatitis, especially if liver biopsy contains plenty of plasma cells To note: there have been documented cases of levels >1:160 that were not AIH.
Primary biliary cirrhosis 0 - 50% of cases
Cryptogenic cirrhosis 0 - 1% of cases
Viral hepatitis 1 - 2% of cases
Welcome to the forum. So sorry to hear about your health problems.
You might want to post your question in the hepatitus autoimmune forum.
Thank you for the info the first test didn't contain a titre so I just had more bloodwork done for the titre and a repeat ana. At this point it would not surprise me one bit for it to be positive I'm just a little confused that if I am truely positive why am I not having more hep symptoms? I guess thats good I don't want to wish anymore bad stuff on me. I'll let you know how it turns out.
Hello. I got my blood tests results back and the AntiSmooth Muscle came back negative. This has everyone confused so I was asked to contact my doctor at UPenn. Because the pain I have is so massive we're going to repeat everything. The USEndoscopy, bloodwork, small bowel and I think she want's me to swallow that pill that takes pictures of your insides. I hadn't seen her in a few months and honestly I think she was frustrated because it would seem nothing would be easy to find. I have a few of the characistics of pancreatitis. Its been a year since we've done all this stuff so now maybe some new info will come to light. Still confused but hopefully some clarity will soon follow.