Tsh-16.3, Thyroid peroxidase- 863.07, thyroglobulin- 17.61, TSI- <89%, normal T3/T4. I've had a radical nephrectomy from renal cell carcinoma. Positive for Factor V Leiden (homozygous) 2 different blood thinners failed last year with multiple DVT/PE & surgery for an IVC filter. When the nurse called with the above lab results I asked if it's primary hypothyroidism or if it's secondary to something else & all I got was "uhh...uhh...I don't know but take the Levothyroxin (125 mcg) & come back in a month." Almost 3 wks on Levo with no improvement. My fatigue is beyond words, occasional throat issues with raspy voice, facial redness that never goes away, joint inflammation, stiffness & debilitating joint pain 24x7 in my hands, hips, knees, feet & no relief from Tylenol, ibuprofen or tramadol, elbow pain, lower extremity swelling or fluid retention, dry mouth, dry/gritty eyes. I feel like an internal bomb just went off! I work from home but I still have to call in often, I can't do anything I enjoy anymore or even manage basic daily living. I don't know how to advocate for myself because this is all foreign to me. I drive 35 miles to the nearest medical group with the closest specialized medicine 3 hrs away in St Louis. Most morning's are spent in tears due to pain & fatigue. I have no idea what this could be which scares me. What could all of this be?? Do I look for a different endo? Should I find a rheumatologist? I don't know where to start!