I have autoimmune pernicious anaemia (unable to absorb vitamin B12 through the gut). Symptoms occur in the "normal" range. The B12 reference range is far too low in most countries. In Japan, a deficiency is found in levels under 550 pg/ml (400pmol/L). When I corrected my B12 my folate increased as well. Besides autoimmune pernicious anaemia I also have Hashimoto's thyroiditis, alopecia areata, vitiligo and joint hypermobility syndrome.
I looked for possible related autoimmune diseases to hypermobility syndrome and found a study "Ehlers-Danlos syndrome hypermobility type is associated with rheumatic diseases".
From this study...
"We found that several structural deformities or deficiencies (i.e. club foot, hereditary angioedema, primary hypogammaglobulemia), non-inflammatory diseases (fibromyalgia, erythromelaglia), and autoimmune/inflammatory diseases (psoriasis, PsA, AS, RA, inflammatory eye disease, autoimmune thyroiditis, SLE, Crohn’s disease, pernicious anemia, and TRAPS) were significantly more prevalent in the CWU HEDS population than in the general population of the US."
To explain the abbreviations:
CWS HEDS - comprehensive work up Ehlers-Danlos Syndrome hypermobility type
PsA - Psoriatic Arthritis
AS - Ankylosing spondylitis
RA - Rheumatoid Arthritis
SLE - Systemic lupus erythematosus
TRAPS - Tumor Necrosis Factor Receptor Associated Periodic Syndrome
A fatty liver is most commonly due to alcohol or sugar. Dr Lustig has a YouTube video "Sugar The Bitter Truth" that goes into biochemical detail of how sugar and alcohol causes a fatty liver. Prediabetes is 41 to 49 mmol/mol. In some cases a fatty liver can be due to malnutrition, congenital metabolic disorders and excessive use of or toxicity of prescribed medications and pain killers.
Excerpt from B12 awareness...
Causes of vitamin B12 deficiency:
Low stomach acid
Autoimmune pernicious anemia
Gastrectomy, intestinal resection
Gastric bypass surgery
Celiac disease (gluten enteropathy)
Bacterial overgrowth (small bowel)
Advanced liver disease
Transcobalamin II deficiency
Inborn errors of B12 metabolism
Excerpt from RACGP..ANA...
ANA pattern - Associated rheumatic disease..
Systemic lupus erythematosus
Mixed connective tissue disease
Drug induced lupus
Juvenile idiopathic arthritis
Diffuse systemic sclerosis/scleroderma