It kinda looks like the lupus butterfly rash.
I personally would not take Prednisone over a long time,
since it is only meant to be for a very short course.
The problem with prolonged use, is the huge risk of further impairing the adrenals to produce cortisol, besides the fact that it is immuno-suppressive, leaving you vulnerable to infections.
Prednisone as a glucocorticoid analogue drug, down-regulates the body's natural production of glucosteroids.
See an ND, knowledgeable in adrenal issues to help you take care of your adrenals-specially restore cortisol production.
This Prednisone treatment is potentially disastrous and most people who stay on it for long, usually never recover. Sorry, I'm not trying to scare you, but I know people, some very close to me, that went against my advice,
and not even one of them got better!
And as far as the COX-2, I can come up with a few safer and better natural anti-inflammatories, than that. Again the risk-benefit analysis, points to
not taking it.
Can you tell me more about you, in regards to your medical history,
diagnosis, labs, lifestyle, diet, fitness, activity levels, symptoms, surgeries, accidents, traumatic events, childhood illnesses, family situation, stress levels and anything you think will help.
I have absolutely no intention on staying on Prednisone. I am waiting to get into Rheumatology so I can be put back on MTX or another DMARD I have major organ involvement so I have to be careful with what treatments I choose.
What are your safer alternatives? I am taking tumeric but that doesn't help once I'm in a full blown flare
Yes, that's what I figured, just wanted to be sure, so maybe this came across a little too strong.
FYI,here's a biologics natural equivalent supplementation,
from my own independent research, for TNFa inhibition.
A seriously dangerous group of chemicals, released as an immune associated with Chronic Inflammation is Tumor Necrosis Factor (TNF).
TNF actively promotes the degeneration of your cells and neurons!
It is activated by a combination of free radicals and *AGEs (Advanced Glycation End-products)*
To keep TNF as low as possible you need to be taking nutrients that will help, such as a “calorie restriction mimics”.
This is another subject on its own but the best known natural calorie restriction mimics is Resveratrol ( found also in red wine- hmm! not enough though) But only the Trans Resveratrol type should be used.
Suggested synergistic nutrient supplementation:
-Best quality possible and most bioavailable ( by injection?)
Stomach acid destroys most of these nutrients in tablet/liquid/capsule form and the result is poor absorption.
Enteric coated that gets absorbed only in the small intestine is the ultimate delivery method for max absorption.
Or injected if that is possible(Naturopathic Dr.or Functional Medicine Dr.)
Below is a daily average intake recommendation -
Injected, depending convenient treatment schedule and costs. Discuss with practitioner.
· Flavanoids 500-1000
· Alpha lipoic acid 200mg
· Carnosine 150mg
· Turmeric extract 50mg
· Glutathione 50mg
Resveratrol 50mg trans resveratrol only
Biologics, a class of FDA approved drugs for various forms of Arthritis , Psoriasis, Chron's Disease, Ulcerative Colitis and many other conditions, are TNF inhibitors!
The above supplements could potentially have the same or better action without the huge cost ($25.000-35.000 annually!) and the side affects.
It is a viable and “easy” option to explore! However it will require time before any results become apparent.
*( In a nutshell, glycation is a (non-enzymatic) reaction through which glucose molecules and chemicals derived from glucose, known as aldehydes (collectively we can call them all ‘glycating agents’ for ease of understanding), bind themselves to your intra- and extracellular protein molecules. ie. the protein molecules have become ‘glycated’!) The new structures formed by glycated proteins are called AGEs which stands for Advanced Glycation End-products. These are REALLY DANGEROUS molecules when it comes to your health!
If you take in a lot of sugar (simple carbs and sweets) through you diet you’re going to have more glucose molecules floating around inside you and that means more glycation and eventually more AGEs, leading to potentially more damage in various parts, organs and systems of the body.
Researchers have also implicated glycation to Alzheimer’s disease! And there’s more! Glycation contributes to HEART DISEASE. It thickens artery walls and clinical evidence suggests that AGEs are important components in the formation of potentially lethal atherosclerotic plaque – that’s the stuff that can build up to impede and block blood flow in your arteries.
Boswellia is a herb that is a great anti-inflammatory and immmunomodulator.
It inhibits lipoxigenase enzymes, thus impairing the synthesis of Leukotrienes (inflammatory molecules).
Here's the better news: From my above reference to TNF-a (Tumor Necrosis Factor-Alpha) a nasty group of chemical inflammatory agents.
Well, TNF-a causes also connective tissue breakdown. And guess what?
Boswellia can inhibit this destructive process.
So here you have "an attack from the back" as It targets whatever TNF-a
effects, survived the "attack from the front" on TFN-a directly and indirectly
from the aforementioned treatment.
Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA.
"Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to anti-inflammatory Boswellia."
Note: The full effect may take a few weeks of supplementation.
Ensure highest quality of standardised Boswellia serrata extract, containing about 40%of Boswellia acids.
There seem to be no established guidelines for dosage, but about 500mg x2 daily with food, is consistent with most practitioners' recommendations.
Please look into this as I feel, is worthwhile and with no known side effects-this has been used in Ayurvedic Medicine for 1000s of years, with no issues, as an anti-inflammatory.
AOR has a nano-available Boswellia supplement,
if you wish to check it out.
I think it has much greater bio-availability.
Taking it with meals which contain fats (best is coconut oil-heated OK-, or olive oil but not heated!)
The effectiveness gets boosted up to 700% (not a typo) when taken with fats!
Give it at least 3 months, to experience notable improvement, however, you may experience results much sooner than that.
This is not intended as a substitute for medical advice.
Let me know if you need any more details or other recommendations.