Aa
MCTD or LPE?
Dr.Kokil you say it may be MCTD, even if SS-A(Ro) >0.2, SS-B(La) >0.2 (negative) and without clinical symptoms? Do you want to tell me that the MCTD is onset and that I will probably begin, in the near future, having clinic symptoms and do you suspect it because of the raising RNP in the past 2.5years?
Thankyou in advance
P.S. I had broken capillaries on one cheek for 2.5 years, now (after vacation) I have them as well on the other cheek, maybe symptomatic for butterfly rash?
Thankyou in advance
P.S. I had broken capillaries on one cheek for 2.5 years, now (after vacation) I have them as well on the other cheek, maybe symptomatic for butterfly rash?
Respecte Doctor isn't U1-RNP of bigger significance for MCTD?
My U1-RNP is >0.2
Can the raising RNP cause a higher titre of U1-RNP? Which of these two antibodies is the "mother"?
My U1-RNP is >0.2
Can the raising RNP cause a higher titre of U1-RNP? Which of these two antibodies is the "mother"?
MEDICAL PROFESSIONAL
Hi!
Positive SS-A (Ro) (a value equal to or above 1.0 U) is indicative of Sjogren’s syndrome (SS), lupus, SS/SLE (lupus) overlap syndrome, primary biliary cirrhosis and subacute cutaneous LE (SCLE). Similarly, SS-B (or anti-La) more than 1.0 U is also considered positive. In, your case, both are negative. So, these conditions are ruled out. Also, Sm and dsDNA antibodies are normal. Only RNP is high and persisting. Any value above 1.0IU is considered positive. However, if you really have a connective tissue disease like theones mentioned above or a MCTD, then the RNP will be much higher. Since, RNP is on the higher side or detectable, chances of MCTD developing in future is always there as you seem to be having a rising titre. However, nothing can be said for sure. Hope this helps. Take care!
The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you. The advice may not be completely correct for you as the doctor cannot examine you and does not know your complete medical history. Hence this reply to your post should only be considered as a guiding line and you must consult your doctor at the earliest for your medical problem.
Positive SS-A (Ro) (a value equal to or above 1.0 U) is indicative of Sjogren’s syndrome (SS), lupus, SS/SLE (lupus) overlap syndrome, primary biliary cirrhosis and subacute cutaneous LE (SCLE). Similarly, SS-B (or anti-La) more than 1.0 U is also considered positive. In, your case, both are negative. So, these conditions are ruled out. Also, Sm and dsDNA antibodies are normal. Only RNP is high and persisting. Any value above 1.0IU is considered positive. However, if you really have a connective tissue disease like theones mentioned above or a MCTD, then the RNP will be much higher. Since, RNP is on the higher side or detectable, chances of MCTD developing in future is always there as you seem to be having a rising titre. However, nothing can be said for sure. Hope this helps. Take care!
The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you. The advice may not be completely correct for you as the doctor cannot examine you and does not know your complete medical history. Hence this reply to your post should only be considered as a guiding line and you must consult your doctor at the earliest for your medical problem.
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