The presence of autoimmune antibodies, anti-nuclear antibodies and elevated CRP indicate a possible autoimmune disease. Unfortunately, the most often used treatments suppress the immune system rather than look for a possible cause. When joint pain and loss of mobility and reduced muscle strength are also present, we always suggest that chronic infections could be involved, because certain chronic infections, such as Mycoplasma, Chlamydia, Borrelia, etc., can cause all of the problems that you list and many more. These infections invade the joints, muscle, vascular system and nerves and cause disruptions in cell function, including the release of cellular antigens that can stimulate the immune system to produce autoantibodies against normal cell structures, the hallmark of autoimmune diseases. In cases like yours, treatment of chronic infections, if they are involved, almost always yields relief of signs/symptoms, but antimicrobial treatment can take quite a long time. The reasons for this are that the infections above are generally slow-growing, not very susceptible to treatments like antibiotics, and they hide deep inside tissues where treatments can often be ineffective. More information can be found on our website, www.immed.org under Autoimmune Diseases and Treatment Considerations.