I was diagnosed with a nervous system imbalance called Dysautonomia in 2005. At the time my main problem (and the only symptom I really noticed) was a SEVERE sensitivity to the effects of ALL drugs and herbs. I do NOT mean an allergic reaction. Instead, it was that I experienced the ENORMOUSLY exaggerated effects of whatever herb or medicine it was, even by consuming the smallest amount!!!! And it was not in my head. It was never a sensitivity to foods or anything else. Only medicinal things.
Move forward a couple years: I noticed that the sensitivity to drugs and herbs was temporarily gone whenever I would take Ashwagandha extract daily (which has SOME effect on acetylcholine receptor activity) and as long as I took it daily, it made my sensitivity go away completely.
Move forward another couple years: At some point, something I took CDP Choline (also known as Citicoline) or Choline Bitartrate and they left me PERMANENTLY UNAFFECTED by herbs/drugs and permanently disabled me with the worst chronic fatigue of my life. As a matter of fact, some drugs and herbs even have the opposite effects than intended now, and I can barely move I'm so fatigued. No supplements, herbs, or drugs seem to have the intended effects, and I cannot reverse the effect back to how things were. Any idea what happened? The only thing I could have possibly combined with the CDP-Choline or Choline Bitartrate is Kava and/or Ashwagandha. How do you restore sensitivities once cholinergics took them away? Any idea what is going on? Please help.