My wife took wellbutrin for two years and then switched to Bupropion SR "generic"for the last three years. This was originally prescribed for a bipolar disorder/mood swings/depression. She had a history of drug use for 5 years. Included meth,speed,cocaine,alchohol,xtacy and GHB. I am sure this caused some chemical imbalances in the brain. She was clean for 5 years before being diagnosed as bipolar and given Wellbutrin. Now that almost all Psychiatrists are just script writers and don't actually council their patients I am wondering how they can make a real assesment for this medication. So here I am. I noticed that when she recieved a new script from Medco, the pills were a different color and it said Bupropion HCL SR instead of Bupropion SR. They assure us they are the same but with the mood swings and agrevation I have observed in the last week. "Something is different". I guess my question would be since she has been totally sober for the last ten years or so and has been taking a lower dose for the last year, 150 mg, I am wondering if she should just stop. Will seratonin levels ever come back to normal or is this going to be a life long battle?